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DIVALPROEX SODIUM vs TRILEPTAL

Independent side-by-side comparison.

Rated against independent regulatory sources·Last updated August 20, 2026·How we rate

Possible drug interaction. DIVALPROEX SODIUM and TRILEPTAL are different prescription medicines. Combining or switching between them can cause interactions — talk to a pharmacist or prescriber before making changes. This page is not medical advice.

divalproex sodiumtrileptal

Rating

68/100
70/100

Pharmacy pays

~$5.99 /30
~$5.03 /30

Type

RX
RX

Active ingredient

DIVALPROEX SODIUM
OXCARBAZEPINE

Manufacturer

Aurobindo Pharma Ltd
Novartis

Dosage forms

Capsule, Oral pellets, Capsule, delayed release, Tablet, delayed release, Tablet, extended release
Suspension, Tablet

Drug class

Anti-Epileptic Agent
Anti-Epileptic Agent

Boxed warning

Boxed warning
None

Half-life

about 9 to 16 hours (the label's mean terminal half-life range for valproate monotherapy)
about 2 hours (immediate-release tablets and oral suspension)

Treats

Bipolar Disorder, Epilepsy, Absence Epilepsy
Partial Epilepsies

Frequently asked questions

Which is better-rated, Divalproex Sodium or Trileptal?

By our independent rating, Trileptal scores higher — 3.5 vs 3.4 out of 5 for Divalproex Sodium. Ratings are based on FDA regulatory (recall-safety) data.

Which is cheaper, Divalproex Sodium or Trileptal?

Trileptal costs pharmacies less to acquire — about $5.03 vs $5.99 for a 30-count supply, per the CMS NADAC survey. That gap is in the pharmacy's cost of goods, not necessarily in what you pay: your price is set afterwards by your insurer and the pharmacy.

What is the difference between Divalproex Sodium and Trileptal?

Divalproex Sodium contains Divalproex Sodium, while Trileptal contains Oxcarbazepine — they have different active ingredients.

Ratings are based on FDA regulatory (recall-safety) data. This comparison is for general reference only — not medical advice. Always consult a licensed professional before choosing or switching a medication.