DIVALPROEX SODIUM vs GRALISE

Independent side-by-side comparison.

Rated against independent regulatory sources·Last updated August 20, 2026·How we rate

Possible drug interaction. DIVALPROEX SODIUM and GRALISE are different prescription medicines. Combining or switching between them can cause interactions — talk to a pharmacist or prescriber before making changes. This page is not medical advice.

Attribute	DIVALPROEX SODIUM	GRALISE
Rating	68/100	New
Pharmacy pays	~$5.99 /30	~$1.22 /30
Type	RX	RX
Active ingredient	DIVALPROEX SODIUM	GABAPENTIN
Manufacturer	Aurobindo Pharma Ltd	Almatica
Dosage forms	Capsule, Oral pellets, Capsule, delayed release, Tablet, delayed release, Tablet, extended release	Tablet
Drug class	Anti-Epileptic Agent	Anti-Epileptic Agent
Boxed warning	Boxed warning	None
Half-life	about 9 to 16 hours (the label's mean terminal half-life range for valproate monotherapy)	about 5 to 7 hours in adults with normal kidney function
Treats	Bipolar Disorder, Epilepsy, Absence Epilepsy	Bipolar Disorder, Partial Epilepsies, Phobic Disorders

divalproex sodium gralise

Rating

68/100

New

Pharmacy pays

~$5.99 /30

~$1.22 /30

Type

Active ingredient

DIVALPROEX SODIUM

GABAPENTIN

Manufacturer

Aurobindo Pharma Ltd

Almatica

Dosage forms

Capsule, Oral pellets, Capsule, delayed release, Tablet, delayed release, Tablet, extended release

Tablet

Drug class

Anti-Epileptic Agent

Boxed warning

None

Half-life

about 9 to 16 hours (the label's mean terminal half-life range for valproate monotherapy)

about 5 to 7 hours in adults with normal kidney function

Treats

Bipolar Disorder, Epilepsy, Absence Epilepsy

Bipolar Disorder, Partial Epilepsies, Phobic Disorders

Frequently asked questions

Which is cheaper, Divalproex Sodium or Gralise?

Gralise costs pharmacies less to acquire — about $1.22 vs $5.99 for a 30-count supply, per the CMS NADAC survey. That gap is in the pharmacy's cost of goods, not necessarily in what you pay: your price is set afterwards by your insurer and the pharmacy.

What is the difference between Divalproex Sodium and Gralise?

Divalproex Sodium contains Divalproex Sodium, while Gralise contains Gabapentin — they have different active ingredients.

Ratings are based on FDA regulatory (recall-safety) data. This comparison is for general reference only — not medical advice. Always consult a licensed professional before choosing or switching a medication.