DIPROLENE AF vs HYDROCORTONE

Independent side-by-side comparison.

Rated against independent regulatory sources·Last updated October 8, 2026·How we rate

Possible drug interaction. DIPROLENE AF and HYDROCORTONE are different prescription medicines. Combining or switching between them can cause interactions — talk to a pharmacist or prescriber before making changes. This page is not medical advice.

Attribute	DIPROLENE AF	HYDROCORTONE
Rating	72/100	72/100
Pharmacy pays	—	$0.14 /g
Type	RX	RX
Active ingredient	BETAMETHASONE DIPROPIONATE	HYDROCORTISONE ACETATE
Manufacturer	Organon	Merck
Dosage forms	Topical, Augmented	Injectable, Tablet
Drug class	Corticosteroid	Corticosteroid
Boxed warning	None	None
Half-life	—	about 1.5 hours
Treats	Atopic Dermatitis, Facial Dermatoses, Foot Dermatoses	Adrenal Insufficiency, Congenital Adrenal Hyperplasia, Ulcerative Colitis

diprolene af hydrocortone

Rating

72/100

Pharmacy pays

—

$0.14 /g

Type

Active ingredient

BETAMETHASONE DIPROPIONATE

HYDROCORTISONE ACETATE

Manufacturer

Organon

Merck

Dosage forms

Topical, Augmented

Injectable, Tablet

Drug class

Corticosteroid

Boxed warning

None

Half-life

—

about 1.5 hours

Treats

Atopic Dermatitis, Facial Dermatoses, Foot Dermatoses

Adrenal Insufficiency, Congenital Adrenal Hyperplasia, Ulcerative Colitis

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Frequently asked questions

Which is better-rated, Diprolene Af or Hydrocortone?

Diprolene Af and Hydrocortone are tied at 3.6 out of 5 by our independent rating.

What is the difference between Diprolene Af and Hydrocortone?

Diprolene Af contains Betamethasone Dipropionate, while Hydrocortone contains Hydrocortisone Acetate — they have different active ingredients.

Ratings are based on FDA regulatory (recall-safety) data. This comparison is for general reference only — not medical advice. Always consult a licensed professional before choosing or switching a medication.