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DILAUDID vs RYZOLT

Independent side-by-side comparison.

Rated against independent regulatory sources·Last updated August 19, 2026·How we rate

Possible drug interaction. DILAUDID and RYZOLT are different prescription medicines. Combining or switching between them can cause interactions — talk to a pharmacist or prescriber before making changes. This page is not medical advice.

Rating

68/100
New

Pharmacy pays

$0.57 /mL
~$0.72 /30

Type

RX
RX

Active ingredient

HYDROMORPHONE HYDROCHLORIDE
TRAMADOL HYDROCHLORIDE

Dosage forms

Injectable, Solution, Tablet
Tablet, extended release

Drug class

Opioid Agonist
Opioid Agonist

Boxed warning

Half-life

about 2.3 hours (terminal elimination half-life after an intravenous dose); after an oral dose the label reports a mean T½ of about 2.6 hours for the 8 mg tablet and 2.8 hours for the oral liquid
about 6 hours (mean terminal elimination half-life of tramadol in healthy adults)

Treats

Cough, Postoperative Pain
Pain

Frequently asked questions

What is the difference between Dilaudid and Ryzolt?

Dilaudid contains Hydromorphone Hydrochloride, while Ryzolt contains Tramadol Hydrochloride — they have different active ingredients.

Ratings are based on FDA regulatory (recall-safety) data. This comparison is for general reference only — not medical advice. Always consult a licensed professional before choosing or switching a medication.