DILAUDID vs OPANA

Independent side-by-side comparison.

Rated against independent regulatory sources·Last updated August 23, 2026·How we rate

Possible drug interaction. DILAUDID and OPANA are different prescription medicines. Combining or switching between them can cause interactions — talk to a pharmacist or prescriber before making changes. This page is not medical advice.

Attribute	DILAUDID	OPANA
Rating	68/100	72/100
Pharmacy pays	$0.57 /mL	~$36.74 /30
Type	RX	RX
Active ingredient	HYDROMORPHONE HYDROCHLORIDE	OXYMORPHONE HYDROCHLORIDE
Manufacturer	Fresenius Kabi USA	Endo Pharms
Dosage forms	Injectable, Solution, Tablet	Tablet, Injectable
Drug class	Opioid Agonist	Opioid Agonist
Boxed warning	Boxed warning	None
Half-life	about 2.3 hours (terminal elimination half-life after an intravenous dose); after an oral dose the label reports a mean T½ of about 2.6 hours for the 8 mg tablet and 2.8 hours for the oral liquid	—
Treats	Cough, Postoperative Pain	Pain

dilaudid opana

Rating

68/100

72/100

Pharmacy pays

$0.57 /mL

~$36.74 /30

Type

Active ingredient

HYDROMORPHONE HYDROCHLORIDE

OXYMORPHONE HYDROCHLORIDE

Manufacturer

Fresenius Kabi USA

Endo Pharms

Dosage forms

Injectable, Solution, Tablet

Tablet, Injectable

Drug class

Opioid Agonist

Boxed warning

None

Half-life

about 2.3 hours (terminal elimination half-life after an intravenous dose); after an oral dose the label reports a mean T½ of about 2.6 hours for the 8 mg tablet and 2.8 hours for the oral liquid

—

Treats

Cough, Postoperative Pain

Pain

Frequently asked questions

Which is better-rated, Dilaudid or Opana?

By our independent rating, Opana scores higher — 3.6 vs 3.4 out of 5 for Dilaudid. Ratings are based on FDA regulatory (recall-safety) data.

What is the difference between Dilaudid and Opana?

Dilaudid contains Hydromorphone Hydrochloride, while Opana contains Oxymorphone Hydrochloride — they have different active ingredients.

Ratings are based on FDA regulatory (recall-safety) data. This comparison is for general reference only — not medical advice. Always consult a licensed professional before choosing or switching a medication.