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DILAUDID vs METHADOSE

Independent side-by-side comparison.

Rated against independent regulatory sources·Last updated August 21, 2026·How we rate

Possible drug interaction. DILAUDID and METHADOSE are different prescription medicines. Combining or switching between them can cause interactions — talk to a pharmacist or prescriber before making changes. This page is not medical advice.

Rating

68/100
70/100

Pharmacy pays

$0.57 /mL
$0.18 /mL

Type

RX
RX

Active ingredient

HYDROMORPHONE HYDROCHLORIDE
METHADONE HYDROCHLORIDE

Dosage forms

Injectable, Solution, Tablet

Drug class

Opioid Agonist
Opioid Agonist

Half-life

about 2.3 hours (terminal elimination half-life after an intravenous dose); after an oral dose the label reports a mean T½ of about 2.6 hours for the 8 mg tablet and 2.8 hours for the oral liquid
about 8 to 59 hours (terminal/elimination half-life; a very wide range)

Treats

Cough, Postoperative Pain
Opioid-Related Disorders, Intractable Pain

Frequently asked questions

Which is better-rated, Dilaudid or Methadose?

By our independent rating, Methadose scores higher — 3.5 vs 3.4 out of 5 for Dilaudid. Ratings are based on FDA regulatory (recall-safety) data.

Which is cheaper, Dilaudid or Methadose?

Methadose costs pharmacies less to acquire — about $0.18 vs $0.57 per ml, per the CMS NADAC survey. That gap is in the pharmacy's cost of goods, not necessarily in what you pay: your price is set afterwards by your insurer and the pharmacy.

What is the difference between Dilaudid and Methadose?

Dilaudid contains Hydromorphone Hydrochloride, while Methadose contains Methadone Hydrochloride — they have different active ingredients.

Ratings are based on FDA regulatory (recall-safety) data. This comparison is for general reference only — not medical advice. Always consult a licensed professional before choosing or switching a medication.