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DILAUDID vs DURAGESIC-75

Independent side-by-side comparison.

Rated against independent regulatory sources·Last updated August 21, 2026·How we rate

Possible drug interaction. DILAUDID and DURAGESIC-75 are different prescription medicines. Combining or switching between them can cause interactions — talk to a pharmacist or prescriber before making changes. This page is not medical advice.

Rating

68/100
70/100

Pharmacy pays

$0.57 /mL
$9.51 /mL

Type

RX
RX

Active ingredient

HYDROMORPHONE HYDROCHLORIDE
FENTANYL

Dosage forms

Injectable, Solution, Tablet
Film, extended release

Drug class

Opioid Agonist
Opioid Agonist

Boxed warning

Half-life

about 2.3 hours (terminal elimination half-life after an intravenous dose); after an oral dose the label reports a mean T½ of about 2.6 hours for the 8 mg tablet and 2.8 hours for the oral liquid

Treats

Cough, Postoperative Pain
Pain

Frequently asked questions

Which is better-rated, Dilaudid or Duragesic-75?

By our independent rating, Duragesic-75 scores higher — 3.5 vs 3.4 out of 5 for Dilaudid. Ratings are based on FDA regulatory (recall-safety) data.

Which is cheaper, Dilaudid or Duragesic-75?

Dilaudid costs pharmacies less to acquire — about $0.57 vs $9.51 per ml, per the CMS NADAC survey. That gap is in the pharmacy's cost of goods, not necessarily in what you pay: your price is set afterwards by your insurer and the pharmacy.

What is the difference between Dilaudid and Duragesic-75?

Dilaudid contains Hydromorphone Hydrochloride, while Duragesic-75 contains Fentanyl — they have different active ingredients.

Ratings are based on FDA regulatory (recall-safety) data. This comparison is for general reference only — not medical advice. Always consult a licensed professional before choosing or switching a medication.