DILAUDID-HP vs OXYCODONE HYDROCHLORIDE

Independent side-by-side comparison.

Rated against independent regulatory sources·Last updated August 22, 2026·How we rate

Possible drug interaction. DILAUDID-HP and OXYCODONE HYDROCHLORIDE are different prescription medicines. Combining or switching between them can cause interactions — talk to a pharmacist or prescriber before making changes. This page is not medical advice.

Attribute	DILAUDID-HP	OXYCODONE HYDROCHLORIDE
Rating	68/100	70/100
Pharmacy pays	$0.57 /mL	$0.08 /mL
Type	RX	RX
Active ingredient	HYDROMORPHONE HYDROCHLORIDE	OXYCODONE HYDROCHLORIDE
Manufacturer	Fresenius Kabi USA	Vistapharm LLC
Dosage forms	Injectable	Solution, Tablet, Tablet, extended release
Drug class	Opioid Agonist	Opioid Agonist
Boxed warning	Boxed warning	None
Half-life	about 2.3 hours (terminal elimination half-life after an intravenous dose); after an oral dose the label reports a mean T½ of about 2.6 hours for the 8 mg tablet and 2.8 hours for the oral liquid	about 3.5 to 4 hours
Treats	Cough, Postoperative Pain	Postoperative Pain

dilaudid-hp oxycodone hydrochloride

Rating

68/100

70/100

Pharmacy pays

$0.57 /mL

$0.08 /mL

Type

Active ingredient

HYDROMORPHONE HYDROCHLORIDE

OXYCODONE HYDROCHLORIDE

Manufacturer

Fresenius Kabi USA

Vistapharm LLC

Dosage forms

Injectable

Solution, Tablet, Tablet, extended release

Drug class

Opioid Agonist

Boxed warning

None

Half-life

about 2.3 hours (terminal elimination half-life after an intravenous dose); after an oral dose the label reports a mean T½ of about 2.6 hours for the 8 mg tablet and 2.8 hours for the oral liquid

about 3.5 to 4 hours

Treats

Cough, Postoperative Pain

Postoperative Pain

Frequently asked questions

Which is better-rated, Dilaudid-Hp or Oxycodone Hydrochloride?

By our independent rating, Oxycodone Hydrochloride scores higher — 3.5 vs 3.4 out of 5 for Dilaudid-Hp. Ratings are based on FDA regulatory (recall-safety) data.

Which is cheaper, Dilaudid-Hp or Oxycodone Hydrochloride?

Oxycodone Hydrochloride costs pharmacies less to acquire — about $0.08 vs $0.57 per ml, per the CMS NADAC survey. That gap is in the pharmacy's cost of goods, not necessarily in what you pay: your price is set afterwards by your insurer and the pharmacy.

What is the difference between Dilaudid-Hp and Oxycodone Hydrochloride?

Dilaudid-Hp contains Hydromorphone Hydrochloride, while Oxycodone Hydrochloride contains Oxycodone Hydrochloride — they have different active ingredients.

Ratings are based on FDA regulatory (recall-safety) data. This comparison is for general reference only — not medical advice. Always consult a licensed professional before choosing or switching a medication.