DIFLUCAN vs MONISTAT 5

Independent side-by-side comparison.

Rated against independent regulatory sources·Last updated August 12, 2026·How we rate

Possible drug interaction. DIFLUCAN and MONISTAT 5 are different prescription medicines. Combining or switching between them can cause interactions — talk to a pharmacist or prescriber before making changes. This page is not medical advice.

Attribute	DIFLUCAN	MONISTAT 5
Rating	60/100	New
Pharmacy pays	$0.42 /mL	—
Type	RX	RX
Active ingredient	FLUCONAZOLE	MICONAZOLE NITRATE
Manufacturer	Pfizer	Personal Prods
Dosage forms	Powder	Tampon
Drug class	Azole Antifungal	Azole Antifungal
Boxed warning	None	None
Half-life	about 30 hours (range 20 to 50 hours)	—
Treats	Blastomycosis, Chronic Mucocutaneous Candidiasis, Oral Candidiasis	Aspergillosis, Cutaneous Candidiasis, Vulvovaginal Candidiasis

diflucan monistat 5

Rating

60/100

New

Pharmacy pays

$0.42 /mL

—

Type

Active ingredient

FLUCONAZOLE

MICONAZOLE NITRATE

Manufacturer

Pfizer

Personal Prods

Dosage forms

Powder

Tampon

Drug class

Azole Antifungal

Boxed warning

None

Half-life

about 30 hours (range 20 to 50 hours)

—

Treats

Blastomycosis, Chronic Mucocutaneous Candidiasis, Oral Candidiasis

Aspergillosis, Cutaneous Candidiasis, Vulvovaginal Candidiasis

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Frequently asked questions

What is the difference between Diflucan and Monistat 5?

Diflucan contains Fluconazole, while Monistat 5 contains Miconazole Nitrate — they have different active ingredients.

Ratings are based on FDA regulatory (recall-safety) data. This comparison is for general reference only — not medical advice. Always consult a licensed professional before choosing or switching a medication.