DIFLUCAN vs MONISTAT

Independent side-by-side comparison.

Rated against independent regulatory sources·Last updated October 6, 2026·How we rate

Possible drug interaction. DIFLUCAN and MONISTAT are different prescription medicines. Combining or switching between them can cause interactions — talk to a pharmacist or prescriber before making changes. This page is not medical advice.

Attribute	DIFLUCAN	MONISTAT
Rating	56/100	72/100
Pharmacy pays	$0.39 /mL	$0.12 /g
Type	RX	RX
Active ingredient	FLUCONAZOLE	MICONAZOLE
Manufacturer	Pfizer	Janssen Pharms
Dosage forms	Powder	Injectable
Drug class	Azole Antifungal	Azole Antifungal
Boxed warning	None	None
Half-life	about 30 hours (range 20 to 50 hours)	—
Treats	Blastomycosis, Chronic Mucocutaneous Candidiasis, Oral Candidiasis	Aspergillosis, Cutaneous Candidiasis, Vulvovaginal Candidiasis

diflucan monistat

Rating

56/100

72/100

Pharmacy pays

$0.39 /mL

$0.12 /g

Type

Active ingredient

FLUCONAZOLE

MICONAZOLE

Manufacturer

Pfizer

Janssen Pharms

Dosage forms

Powder

Injectable

Drug class

Azole Antifungal

Boxed warning

None

Half-life

about 30 hours (range 20 to 50 hours)

—

Treats

Blastomycosis, Chronic Mucocutaneous Candidiasis, Oral Candidiasis

Aspergillosis, Cutaneous Candidiasis, Vulvovaginal Candidiasis

Get diflucan

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Frequently asked questions

Which is better-rated, Diflucan or Monistat?

By our independent rating, Monistat scores higher — 3.6 vs 2.8 out of 5 for Diflucan. Ratings are based on FDA regulatory (recall-safety) data.

What is the difference between Diflucan and Monistat?

Diflucan contains Fluconazole, while Monistat contains Miconazole — they have different active ingredients.

Ratings are based on FDA regulatory (recall-safety) data. This comparison is for general reference only — not medical advice. Always consult a licensed professional before choosing or switching a medication.