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DIFLUCAN vs LOTRIMIN

Independent side-by-side comparison.

Rated against independent regulatory sources·Last updated August 21, 2026·How we rate

Possible drug interaction. DIFLUCAN and LOTRIMIN are different prescription medicines. Combining or switching between them can cause interactions — talk to a pharmacist or prescriber before making changes. This page is not medical advice.

Rating

60/100
New

Pharmacy pays

$0.42 /mL
$0.21 /mL

Type

RX
RX

Active ingredient

FLUCONAZOLE
CLOTRIMAZOLE

Dosage forms

Powder
Topical

Drug class

Azole Antifungal
Azole Antifungal

Boxed warning

None
None

Half-life

about 30 hours (range 20 to 50 hours)

Treats

Blastomycosis, Chronic Mucocutaneous Candidiasis, Oral Candidiasis
Cutaneous Candidiasis, Oral Candidiasis, Vulvovaginal Candidiasis

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Frequently asked questions

Which is cheaper, Diflucan or Lotrimin?

Lotrimin costs pharmacies less to acquire — about $0.21 vs $0.42 per ml, per the CMS NADAC survey. That gap is in the pharmacy's cost of goods, not necessarily in what you pay: your price is set afterwards by your insurer and the pharmacy.

What is the difference between Diflucan and Lotrimin?

Diflucan contains Fluconazole, while Lotrimin contains Clotrimazole — they have different active ingredients.

Ratings are based on FDA regulatory (recall-safety) data. This comparison is for general reference only — not medical advice. Always consult a licensed professional before choosing or switching a medication.