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DIFLUCAN IN SODIUM CHLORIDE 0.9% vs LOTRIMIN

Independent side-by-side comparison.

Rated against independent regulatory sources·Last updated August 21, 2026·How we rate

Possible drug interaction. DIFLUCAN IN SODIUM CHLORIDE 0.9% and LOTRIMIN are different prescription medicines. Combining or switching between them can cause interactions — talk to a pharmacist or prescriber before making changes. This page is not medical advice.

Rating

64/100
New

Pharmacy pays

$0.42 /mL
$0.21 /mL

Type

RX
RX

Active ingredient

FLUCONAZOLE
CLOTRIMAZOLE

Dosage forms

Injectable
Topical

Drug class

Azole Antifungal
Azole Antifungal

Boxed warning

None
None

Half-life

about 30 hours (range 20 to 50 hours)

Treats

Blastomycosis, Chronic Mucocutaneous Candidiasis, Oral Candidiasis
Cutaneous Candidiasis, Oral Candidiasis, Vulvovaginal Candidiasis

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Frequently asked questions

Which is cheaper, Diflucan in Sodium Chloride 0.9% or Lotrimin?

Lotrimin costs pharmacies less to acquire — about $0.21 vs $0.42 per ml, per the CMS NADAC survey. That gap is in the pharmacy's cost of goods, not necessarily in what you pay: your price is set afterwards by your insurer and the pharmacy.

What is the difference between Diflucan in Sodium Chloride 0.9% and Lotrimin?

Diflucan in Sodium Chloride 0.9% contains Fluconazole, while Lotrimin contains Clotrimazole — they have different active ingredients.

Ratings are based on FDA regulatory (recall-safety) data. This comparison is for general reference only — not medical advice. Always consult a licensed professional before choosing or switching a medication.