DIFICID vs TYZAVAN

Independent side-by-side comparison.

Rated against independent regulatory sources·Last updated August 18, 2026·How we rate

Possible drug interaction. DIFICID and TYZAVAN are different prescription medicines. Combining or switching between them can cause interactions — talk to a pharmacist or prescriber before making changes. This page is not medical advice.

Attribute	DIFICID	TYZAVAN
Rating	72/100	72/100
Pharmacy pays	~$4759.74 /30	$1.49 /mL
Type	RX	RX
Active ingredient	FIDAXOMICIN	VANCOMYCIN HYDROCHLORIDE
Manufacturer	Cubist Pharms LLC	Hikma
Dosage forms	Powder	Injectable
Drug class	Macrolide Antibacterial	Glycopeptide Antibacterial
Boxed warning	None	Boxed warning
Treats	Pseudomembranous Enterocolitis	Diarrhea, Bacterial Endocarditis, Pseudomembranous Enterocolitis

dificid tyzavan

Rating

72/100

Pharmacy pays

~$4759.74 /30

$1.49 /mL

Type

Active ingredient

FIDAXOMICIN

VANCOMYCIN HYDROCHLORIDE

Manufacturer

Cubist Pharms LLC

Hikma

Dosage forms

Powder

Injectable

Drug class

Macrolide Antibacterial

Glycopeptide Antibacterial

Boxed warning

None

Boxed warning

Treats

Pseudomembranous Enterocolitis

Diarrhea, Bacterial Endocarditis, Pseudomembranous Enterocolitis

Frequently asked questions

Which is better-rated, Dificid or Tyzavan?

Dificid and Tyzavan are tied at 3.6 out of 5 by our independent rating.

What is the difference between Dificid and Tyzavan?

Dificid contains Fidaxomicin, while Tyzavan contains Vancomycin Hydrochloride — they have different active ingredients.

Ratings are based on FDA regulatory (recall-safety) data. This comparison is for general reference only — not medical advice. Always consult a licensed professional before choosing or switching a medication.