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DIFFERIN vs TAZORAC

Independent side-by-side comparison.

Rated against independent regulatory sources·Last updated August 22, 2026·How we rate

Possible drug interaction. DIFFERIN and TAZORAC are different prescription medicines. Combining or switching between them can cause interactions — talk to a pharmacist or prescriber before making changes. This page is not medical advice.

Rating

New
New

Pharmacy pays

$0.51 /g
$6.80 /g

Type

RX
RX

Active ingredient

ADAPALENE
TAZAROTENE

Dosage forms

Topical
Topical

Drug class

Retinoid
Retinoid

Boxed warning

None
None

Treats

Acne Vulgaris
Acne Vulgaris, Psoriasis

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Frequently asked questions

Which is cheaper, Differin or Tazorac?

Differin costs pharmacies less to acquire — about $0.51 vs $6.80 per gm, per the CMS NADAC survey. That gap is in the pharmacy's cost of goods, not necessarily in what you pay: your price is set afterwards by your insurer and the pharmacy.

What is the difference between Differin and Tazorac?

Differin contains Adapalene, while Tazorac contains Tazarotene — they have different active ingredients.

Ratings are based on FDA regulatory (recall-safety) data. This comparison is for general reference only — not medical advice. Always consult a licensed professional before choosing or switching a medication.