DIFFERIN vs RETIN-A
Independent side-by-side comparison.
Possible drug interaction. DIFFERIN and RETIN-A are different prescription medicines. Combining or switching between them can cause interactions — talk to a pharmacist or prescriber before making changes. This page is not medical advice.
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Pharmacy pays
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Boxed warning
Treats
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Frequently asked questions
Which is cheaper, Differin or Retin-A?
Differin costs pharmacies less to acquire — about $0.51 vs $1.05 per gm, per the CMS NADAC survey. That gap is in the pharmacy's cost of goods, not necessarily in what you pay: your price is set afterwards by your insurer and the pharmacy.
What is the difference between Differin and Retin-A?
Differin contains Adapalene, while Retin-A contains Tretinoin — they have different active ingredients.
Ratings are based on FDA regulatory (recall-safety) data. This comparison is for general reference only — not medical advice. Always consult a licensed professional before choosing or switching a medication.