DICLOFENAC SODIUM vs ZIPSOR

Independent side-by-side comparison.

Rated against independent regulatory sources·Last updated August 14, 2026·How we rate

Possible drug interaction. DICLOFENAC SODIUM and ZIPSOR are different prescription medicines. Combining or switching between them can cause interactions — talk to a pharmacist or prescriber before making changes. This page is not medical advice.

Attribute	DICLOFENAC SODIUM	ZIPSOR
Rating	70/100	New
Pharmacy pays	$0.36 /mL	$0.36 /mL
Type	RX	RX
Active ingredient	DICLOFENAC SODIUM	DICLOFENAC POTASSIUM
Manufacturer	Amneal	Assertio Speclty
Dosage forms	Solution, Drops, Topical, Tablet, delayed release, Tablet, extended release, Tablet, Kit	Capsule
Drug class	Nonsteroidal Anti-Inflammatory Drug	Nonsteroidal Anti-Inflammatory Drug
Boxed warning	Boxed warning	Boxed warning
Half-life	about 2 hours (terminal/elimination half-life; the label's table gives a mean of 2.3 hours in healthy adults, with wide variation between people — 48% coefficient of variation)	about 2 hours (terminal/elimination half-life; the label's table gives a mean of 2.3 hours in healthy adults, with wide variation between people — 48% coefficient of variation)
Treats	Juvenile Arthritis, Rheumatoid Arthritis, Dysmenorrhea	Juvenile Arthritis, Rheumatoid Arthritis, Dysmenorrhea

diclofenac sodium zipsor

Rating

70/100

New

Pharmacy pays

$0.36 /mL

Type

Active ingredient

DICLOFENAC SODIUM

DICLOFENAC POTASSIUM

Manufacturer

Amneal

Assertio Speclty

Dosage forms

Solution, Drops, Topical, Tablet, delayed release, Tablet, extended release, Tablet, Kit

Capsule

Drug class

Nonsteroidal Anti-Inflammatory Drug

Boxed warning

Half-life

about 2 hours (terminal/elimination half-life; the label's table gives a mean of 2.3 hours in healthy adults, with wide variation between people — 48% coefficient of variation)

Treats

Juvenile Arthritis, Rheumatoid Arthritis, Dysmenorrhea

Frequently asked questions

Which is cheaper, Diclofenac Sodium or Zipsor?

Pharmacies pay about the same to acquire either one — roughly $0.36 per ml, per the CMS NADAC survey. That is not what you will be charged: your price is set by your insurer and the pharmacy, not by what the drug cost them.

What is the difference between Diclofenac Sodium and Zipsor?

Diclofenac Sodium contains Diclofenac Sodium, while Zipsor contains Diclofenac Potassium — they have different active ingredients.

Ratings are based on FDA regulatory (recall-safety) data. This comparison is for general reference only — not medical advice. Always consult a licensed professional before choosing or switching a medication.