DICLOFENAC SODIUM vs NAPROSYN

Independent side-by-side comparison.

Rated against independent regulatory sources·Last updated August 21, 2026·How we rate

Possible drug interaction. DICLOFENAC SODIUM and NAPROSYN are different prescription medicines. Combining or switching between them can cause interactions — talk to a pharmacist or prescriber before making changes. This page is not medical advice.

Attribute	DICLOFENAC SODIUM	NAPROSYN
Rating	70/100	New
Pharmacy pays	$0.36 /mL	$0.06 /mL
Type	RX	RX
Active ingredient	DICLOFENAC SODIUM	NAPROXEN
Manufacturer	Amneal	Atnahs Pharma US
Dosage forms	Solution, Drops, Topical, Tablet, delayed release, Tablet, extended release, Tablet, Kit	Tablet
Drug class	Nonsteroidal Anti-Inflammatory Drug	Nonsteroidal Anti-Inflammatory Drug
Boxed warning	Boxed warning	None
Half-life	about 2 hours (terminal/elimination half-life; the label's table gives a mean of 2.3 hours in healthy adults, with wide variation between people — 48% coefficient of variation)	about 12 to 17 hours
Treats	Juvenile Arthritis, Rheumatoid Arthritis, Dysmenorrhea	Juvenile Arthritis, Rheumatoid Arthritis, Back Pain

diclofenac sodium naprosyn

Rating

70/100

New

Pharmacy pays

$0.36 /mL

$0.06 /mL

Type

Active ingredient

DICLOFENAC SODIUM

NAPROXEN

Manufacturer

Amneal

Atnahs Pharma US

Dosage forms

Solution, Drops, Topical, Tablet, delayed release, Tablet, extended release, Tablet, Kit

Tablet

Drug class

Nonsteroidal Anti-Inflammatory Drug

Boxed warning

None

Half-life

about 2 hours (terminal/elimination half-life; the label's table gives a mean of 2.3 hours in healthy adults, with wide variation between people — 48% coefficient of variation)

about 12 to 17 hours

Treats

Juvenile Arthritis, Rheumatoid Arthritis, Dysmenorrhea

Juvenile Arthritis, Rheumatoid Arthritis, Back Pain

Frequently asked questions

Which is cheaper, Diclofenac Sodium or Naprosyn?

Naprosyn costs pharmacies less to acquire — about $0.06 vs $0.36 per ml, per the CMS NADAC survey. That gap is in the pharmacy's cost of goods, not necessarily in what you pay: your price is set afterwards by your insurer and the pharmacy.

What is the difference between Diclofenac Sodium and Naprosyn?

Diclofenac Sodium contains Diclofenac Sodium, while Naprosyn contains Naproxen — they have different active ingredients.

Ratings are based on FDA regulatory (recall-safety) data. This comparison is for general reference only — not medical advice. Always consult a licensed professional before choosing or switching a medication.