DEXTROAMPHETAMINE SULFATE vs LISDEXAMFETAMINE DIMESYLATE

Independent side-by-side comparison.

Rated against independent regulatory sources·Last updated August 22, 2026·How we rate

Possible drug interaction. DEXTROAMPHETAMINE SULFATE and LISDEXAMFETAMINE DIMESYLATE are different prescription medicines. Combining or switching between them can cause interactions — talk to a pharmacist or prescriber before making changes. This page is not medical advice.

Attribute	DEXTROAMPHETAMINE SULFATE	LISDEXAMFETAMINE DIMESYLATE
Rating	72/100	70/100
Pharmacy pays	~$29.94 /30	—
Type	RX	RX
Active ingredient	DEXTROAMPHETAMINE SULFATE	LISDEXAMFETAMINE DIMESYLATE
Manufacturer	Tris Pharma Inc	Ascent Pharms Inc
Dosage forms	Capsule, extended release, Solution, Tablet	Capsule, Tablet, chewable
Drug class	Central Nervous System Stimulant	Central Nervous System Stimulant
Boxed warning	Boxed warning	Boxed warning
Half-life	—	less than 1 hour (parent drug)
Treats	Attention Deficit Disorder with Hyperactivity, Narcolepsy	Attention Deficit Disorder with Hyperactivity, Binge Drinking

dextroamphetamine sulfate lisdexamfetamine dimesylate

Rating

72/100

70/100

Pharmacy pays

~$29.94 /30

—

Type

Active ingredient

DEXTROAMPHETAMINE SULFATE

LISDEXAMFETAMINE DIMESYLATE

Manufacturer

Tris Pharma Inc

Ascent Pharms Inc

Dosage forms

Capsule, extended release, Solution, Tablet

Capsule, Tablet, chewable

Drug class

Central Nervous System Stimulant

Boxed warning

Half-life

—

less than 1 hour (parent drug)

Treats

Attention Deficit Disorder with Hyperactivity, Narcolepsy

Attention Deficit Disorder with Hyperactivity, Binge Drinking

Frequently asked questions

Which is better-rated, Dextroamphetamine Sulfate or Lisdexamfetamine Dimesylate?

By our independent rating, Dextroamphetamine Sulfate scores higher — 3.6 vs 3.5 out of 5 for Lisdexamfetamine Dimesylate. Ratings are based on FDA regulatory (recall-safety) data.

What is the difference between Dextroamphetamine Sulfate and Lisdexamfetamine Dimesylate?

Dextroamphetamine Sulfate contains Dextroamphetamine Sulfate, while Lisdexamfetamine Dimesylate contains Lisdexamfetamine Dimesylate — they have different active ingredients.

Ratings are based on FDA regulatory (recall-safety) data. This comparison is for general reference only — not medical advice. Always consult a licensed professional before choosing or switching a medication.