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DEXEDRINE SPANSULE vs METHYLPHENIDATE HYDROCHLORIDE

Independent side-by-side comparison.

Rated against independent regulatory sources·Last updated August 19, 2026·How we rate

Possible drug interaction. DEXEDRINE SPANSULE and METHYLPHENIDATE HYDROCHLORIDE are different prescription medicines. Combining or switching between them can cause interactions — talk to a pharmacist or prescriber before making changes. This page is not medical advice.

dexedrine spansulemethylphenidate hydrochloride

Rating

70/100
New

Pharmacy pays

~$29.94 /30
~$18.94 /30

Type

RX
RX

Active ingredient

DEXTROAMPHETAMINE SULFATE
METHYLPHENIDATE HYDROCHLORIDE

Manufacturer

Impax
Alkem Labs Ltd

Dosage forms

Capsule, extended release
Capsule, extended release, Solution, Tablet, Tablet, chewable, Tablet, extended release

Drug class

Central Nervous System Stimulant
Central Nervous System Stimulant

Boxed warning

Boxed warning
None

Half-life

—
about 2.7 hours

Treats

Attention Deficit Disorder with Hyperactivity, Narcolepsy
Attention Deficit Disorder with Hyperactivity, Depressive Disorder, Narcolepsy

Frequently asked questions

Which is cheaper, Dexedrine Spansule or Methylphenidate Hydrochloride?

Methylphenidate Hydrochloride costs pharmacies less to acquire — about $18.94 vs $29.94 for a 30-count supply, per the CMS NADAC survey. That gap is in the pharmacy's cost of goods, not necessarily in what you pay: your price is set afterwards by your insurer and the pharmacy.

What is the difference between Dexedrine Spansule and Methylphenidate Hydrochloride?

Dexedrine Spansule contains Dextroamphetamine Sulfate, while Methylphenidate Hydrochloride contains Methylphenidate Hydrochloride — they have different active ingredients.

Ratings are based on FDA regulatory (recall-safety) data. This comparison is for general reference only — not medical advice. Always consult a licensed professional before choosing or switching a medication.