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DESIPRAMINE HYDROCHLORIDE vs NORTRIPTYLINE HYDROCHLORIDE

Independent side-by-side comparison.

Rated against independent regulatory sources·Last updated August 19, 2026·How we rate

Possible drug interaction. DESIPRAMINE HYDROCHLORIDE and NORTRIPTYLINE HYDROCHLORIDE are different prescription medicines. Combining or switching between them can cause interactions — talk to a pharmacist or prescriber before making changes. This page is not medical advice.

Rating

70/100
68/100

Pharmacy pays

~$8.39 /30
$0.17 /mL

Type

RX
RX

Active ingredient

DESIPRAMINE HYDROCHLORIDE
NORTRIPTYLINE HYDROCHLORIDE

Dosage forms

Tablet
Capsule, Solution

Drug class

Tricyclic Antidepressant
Tricyclic Antidepressant

Boxed warning

None
None

Treats

Attention Deficit Disorder with Hyperactivity, Depressive Disorder, Pain
Anxiety Disorders, Attention Deficit Disorder with Hyperactivity, Depressive Disorder

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Frequently asked questions

Which is better-rated, Desipramine Hydrochloride or Nortriptyline Hydrochloride?

By our independent rating, Desipramine Hydrochloride scores higher — 3.5 vs 3.4 out of 5 for Nortriptyline Hydrochloride. Ratings are based on FDA regulatory (recall-safety) data.

What is the difference between Desipramine Hydrochloride and Nortriptyline Hydrochloride?

Desipramine Hydrochloride contains Desipramine Hydrochloride, while Nortriptyline Hydrochloride contains Nortriptyline Hydrochloride — they have different active ingredients.

Ratings are based on FDA regulatory (recall-safety) data. This comparison is for general reference only — not medical advice. Always consult a licensed professional before choosing or switching a medication.