DESIPRAMINE HYDROCHLORIDE vs DOXEPIN HYDROCHLORIDE

Independent side-by-side comparison.

Rated against independent regulatory sources·Last updated August 21, 2026·How we rate

Possible drug interaction. DESIPRAMINE HYDROCHLORIDE and DOXEPIN HYDROCHLORIDE are different prescription medicines. Combining or switching between them can cause interactions — talk to a pharmacist or prescriber before making changes. This page is not medical advice.

Attribute	DESIPRAMINE HYDROCHLORIDE	DOXEPIN HYDROCHLORIDE
Rating	70/100	70/100
Pharmacy pays	~$8.39 /30	~$4.84 /30
Type	RX	RX
Active ingredient	DESIPRAMINE HYDROCHLORIDE	DOXEPIN HYDROCHLORIDE
Manufacturer	Ani Pharms	Watson Labs
Dosage forms	Tablet	Capsule, Topical, Solution, Tablet
Drug class	Tricyclic Antidepressant	Tricyclic Antidepressant
Boxed warning	None	None
Half-life	—	about 8 to 24 hours (average about 17 hours)
Treats	Attention Deficit Disorder with Hyperactivity, Depressive Disorder, Pain	Anxiety Disorders, Depressive Disorder, Atopic Dermatitis

desipramine hydrochloride doxepin hydrochloride

Rating

70/100

Pharmacy pays

~$8.39 /30

~$4.84 /30

Type

Active ingredient

DESIPRAMINE HYDROCHLORIDE

DOXEPIN HYDROCHLORIDE

Manufacturer

Ani Pharms

Watson Labs

Dosage forms

Tablet

Capsule, Topical, Solution, Tablet

Drug class

Tricyclic Antidepressant

Boxed warning

None

Half-life

—

about 8 to 24 hours (average about 17 hours)

Treats

Attention Deficit Disorder with Hyperactivity, Depressive Disorder, Pain

Anxiety Disorders, Depressive Disorder, Atopic Dermatitis

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Frequently asked questions

Which is better-rated, Desipramine Hydrochloride or Doxepin Hydrochloride?

Desipramine Hydrochloride and Doxepin Hydrochloride are tied at 3.5 out of 5 by our independent rating.

Which is cheaper, Desipramine Hydrochloride or Doxepin Hydrochloride?

Doxepin Hydrochloride costs pharmacies less to acquire — about $4.84 vs $8.39 for a 30-count supply, per the CMS NADAC survey. That gap is in the pharmacy's cost of goods, not necessarily in what you pay: your price is set afterwards by your insurer and the pharmacy.

What is the difference between Desipramine Hydrochloride and Doxepin Hydrochloride?

Desipramine Hydrochloride contains Desipramine Hydrochloride, while Doxepin Hydrochloride contains Doxepin Hydrochloride — they have different active ingredients.

Ratings are based on FDA regulatory (recall-safety) data. This comparison is for general reference only — not medical advice. Always consult a licensed professional before choosing or switching a medication.