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DEPO-SUBQ PROVERA 104 vs MEGESTROL ACETATE

Independent side-by-side comparison.

Rated against independent regulatory sources·Last updated August 17, 2026·How we rate

Possible drug interaction. DEPO-SUBQ PROVERA 104 and MEGESTROL ACETATE are different prescription medicines. Combining or switching between them can cause interactions — talk to a pharmacist or prescriber before making changes. This page is not medical advice.

Rating

64/100
70/100

Pharmacy pays

~$562.79 /30
~$7.14 /30

Type

RX
RX

Active ingredient

MEDROXYPROGESTERONE ACETATE
MEGESTROL ACETATE

Dosage forms

Injectable
Tablet, Suspension

Drug class

Progestin
Progestin

Boxed warning

Treats

Amenorrhea, Breast Neoplasms, Renal Cell Carcinoma
Anorexia, Breast Neoplasms, Cachexia

Frequently asked questions

Which is better-rated, Depo-Subq Provera 104 or Megestrol Acetate?

By our independent rating, Megestrol Acetate scores higher — 3.5 vs 3.2 out of 5 for Depo-Subq Provera 104. Ratings are based on FDA regulatory (recall-safety) data.

Which is cheaper, Depo-Subq Provera 104 or Megestrol Acetate?

Megestrol Acetate costs pharmacies less to acquire — about $7.14 vs $562.79 for a 30-count supply, per the CMS NADAC survey. That gap is in the pharmacy's cost of goods, not necessarily in what you pay: your price is set afterwards by your insurer and the pharmacy.

What is the difference between Depo-Subq Provera 104 and Megestrol Acetate?

Depo-Subq Provera 104 contains Medroxyprogesterone Acetate, while Megestrol Acetate contains Megestrol Acetate — they have different active ingredients.

Ratings are based on FDA regulatory (recall-safety) data. This comparison is for general reference only — not medical advice. Always consult a licensed professional before choosing or switching a medication.