DEPO-SUBQ PROVERA 104 vs MEGACE ES

Independent side-by-side comparison.

Rated against independent regulatory sources·Last updated August 22, 2026·How we rate

Possible drug interaction. DEPO-SUBQ PROVERA 104 and MEGACE ES are different prescription medicines. Combining or switching between them can cause interactions — talk to a pharmacist or prescriber before making changes. This page is not medical advice.

Attribute	DEPO-SUBQ PROVERA 104	MEGACE ES
Rating	64/100	New
Pharmacy pays	~$562.79 /30	~$7.14 /30
Type	RX	RX
Active ingredient	MEDROXYPROGESTERONE ACETATE	MEGESTROL ACETATE
Manufacturer	Pfizer	Endo Operations
Dosage forms	Injectable	Suspension
Drug class	Progestin	Progestin
Boxed warning	Boxed warning	None
Treats	Amenorrhea, Breast Neoplasms, Renal Cell Carcinoma	Anorexia, Breast Neoplasms, Cachexia

depo-subq provera 104 megace es

Rating

64/100

New

Pharmacy pays

~$562.79 /30

~$7.14 /30

Type

Active ingredient

MEDROXYPROGESTERONE ACETATE

MEGESTROL ACETATE

Manufacturer

Pfizer

Endo Operations

Dosage forms

Injectable

Suspension

Drug class

Progestin

Boxed warning

None

Treats

Amenorrhea, Breast Neoplasms, Renal Cell Carcinoma

Anorexia, Breast Neoplasms, Cachexia

Frequently asked questions

Which is cheaper, Depo-Subq Provera 104 or Megace Es?

Megace Es costs pharmacies less to acquire — about $7.14 vs $562.79 for a 30-count supply, per the CMS NADAC survey. That gap is in the pharmacy's cost of goods, not necessarily in what you pay: your price is set afterwards by your insurer and the pharmacy.

What is the difference between Depo-Subq Provera 104 and Megace Es?

Depo-Subq Provera 104 contains Medroxyprogesterone Acetate, while Megace Es contains Megestrol Acetate — they have different active ingredients.

Ratings are based on FDA regulatory (recall-safety) data. This comparison is for general reference only — not medical advice. Always consult a licensed professional before choosing or switching a medication.