DEPO-PROVERA vs SKYLA

Independent side-by-side comparison.

Rated against independent regulatory sources·Last updated August 22, 2026·How we rate

Possible drug interaction. DEPO-PROVERA and SKYLA are different prescription medicines. Combining or switching between them can cause interactions — talk to a pharmacist or prescriber before making changes. This page is not medical advice.

Attribute	DEPO-PROVERA	SKYLA
Rating	64/100	New
Pharmacy pays	~$562.79 /30	~$192.31 /30
Type	RX	RX
Active ingredient	MEDROXYPROGESTERONE ACETATE	LEVONORGESTREL
Manufacturer	Pfizer	Bayer Hlthcare
Dosage forms	Injectable	IUD
Drug class	Progestin	Progestin
Boxed warning	Boxed warning	None
Half-life	—	about 36 hours (36 ± 13 hours at steady state)
Treats	Amenorrhea, Breast Neoplasms, Renal Cell Carcinoma	—

depo-provera skyla

Rating

64/100

New

Pharmacy pays

~$562.79 /30

~$192.31 /30

Type

Active ingredient

MEDROXYPROGESTERONE ACETATE

LEVONORGESTREL

Manufacturer

Pfizer

Bayer Hlthcare

Dosage forms

Injectable

IUD

Drug class

Progestin

Boxed warning

None

Half-life

—

about 36 hours (36 ± 13 hours at steady state)

Treats

Amenorrhea, Breast Neoplasms, Renal Cell Carcinoma

—

Frequently asked questions

Which is cheaper, Depo-Provera or Skyla?

Skyla costs pharmacies less to acquire — about $192.31 vs $562.79 for a 30-count supply, per the CMS NADAC survey. That gap is in the pharmacy's cost of goods, not necessarily in what you pay: your price is set afterwards by your insurer and the pharmacy.

What is the difference between Depo-Provera and Skyla?

Depo-Provera contains Medroxyprogesterone Acetate, while Skyla contains Levonorgestrel — they have different active ingredients.

Ratings are based on FDA regulatory (recall-safety) data. This comparison is for general reference only — not medical advice. Always consult a licensed professional before choosing or switching a medication.