DEPO-MEDROL vs METHYLPREDNISOLONE ACETATE

Independent side-by-side comparison.

Rated against independent regulatory sources·Last updated August 19, 2026·How we rate

Attribute	DEPO-MEDROL	METHYLPREDNISOLONE ACETATE
Rating	56/100	70/100
Pharmacy pays	~$30.69 /30	~$30.69 /30
Type	RX	RX
Active ingredient	METHYLPREDNISOLONE ACETATE	METHYLPREDNISOLONE ACETATE
Manufacturer	Pfizer	Amneal
Dosage forms	Injectable	Injectable
Drug class	Corticosteroid	Corticosteroid
Boxed warning	None	None
Treats	Adrenal Insufficiency, Asthma, Berylliosis	Adrenal Insufficiency, Asthma, Berylliosis

depo-medrol methylprednisolone acetate

Rating

56/100

70/100

Pharmacy pays

~$30.69 /30

Type

Active ingredient

METHYLPREDNISOLONE ACETATE

Manufacturer

Pfizer

Amneal

Dosage forms

Injectable

Drug class

Corticosteroid

Boxed warning

None

Treats

Adrenal Insufficiency, Asthma, Berylliosis

Frequently asked questions

Which is better-rated, Depo-Medrol or Methylprednisolone Acetate?

By our independent rating, Methylprednisolone Acetate scores higher — 3.5 vs 2.8 out of 5 for Depo-Medrol. Ratings are based on FDA regulatory (recall-safety) data.

Which is cheaper, Depo-Medrol or Methylprednisolone Acetate?

Pharmacies pay about the same to acquire either one — roughly $30.69 for a 30-count supply, per the CMS NADAC survey. That is not what you will be charged: your price is set by your insurer and the pharmacy, not by what the drug cost them.

What is the difference between Depo-Medrol and Methylprednisolone Acetate?

Both Depo-Medrol and Methylprednisolone Acetate share the active ingredient Methylprednisolone Acetate.

Ratings are based on FDA regulatory (recall-safety) data. This comparison is for general reference only — not medical advice. Always consult a licensed professional before choosing or switching a medication.