DEPO-MEDROL vs FML

Independent side-by-side comparison.

Rated against independent regulatory sources·Last updated October 5, 2026·How we rate

Possible drug interaction. DEPO-MEDROL and FML are different prescription medicines. Combining or switching between them can cause interactions — talk to a pharmacist or prescriber before making changes. This page is not medical advice.

Attribute	DEPO-MEDROL	FML
Rating	52/100	72/100
Pharmacy pays	~$30.69 /30	$12.62 /mL
Type	RX	RX
Active ingredient	METHYLPREDNISOLONE ACETATE	FLUOROMETHOLONE
Manufacturer	Pfizer	Allergan
Dosage forms	Injectable	Drops
Drug class	Corticosteroid	Corticosteroid
Boxed warning	None	None
Treats	Adrenal Insufficiency, Asthma, Berylliosis	Conjunctivitis, Inflammation, Keratitis

depo-medrol fml

Rating

52/100

72/100

Pharmacy pays

~$30.69 /30

$12.62 /mL

Type

Active ingredient

METHYLPREDNISOLONE ACETATE

FLUOROMETHOLONE

Manufacturer

Pfizer

Allergan

Dosage forms

Injectable

Drops

Drug class

Corticosteroid

Boxed warning

None

Treats

Adrenal Insufficiency, Asthma, Berylliosis

Conjunctivitis, Inflammation, Keratitis

Frequently asked questions

Which is better-rated, Depo-Medrol or Fml?

By our independent rating, Fml scores higher — 3.6 vs 2.6 out of 5 for Depo-Medrol. Ratings are based on FDA regulatory (recall-safety) data.

What is the difference between Depo-Medrol and Fml?

Depo-Medrol contains Methylprednisolone Acetate, while Fml contains Fluorometholone — they have different active ingredients.

Ratings are based on FDA regulatory (recall-safety) data. This comparison is for general reference only — not medical advice. Always consult a licensed professional before choosing or switching a medication.