DEPEN vs TRIENTINE HYDROCHLORIDE

Independent side-by-side comparison.

Rated against independent regulatory sources·Last updated June 7, 2026·How we rate

Possible drug interaction. DEPEN and TRIENTINE HYDROCHLORIDE are different prescription medicines. Combining or switching between them can cause interactions — talk to a pharmacist or prescriber before making changes. This page is not medical advice.

Attribute	DEPEN	TRIENTINE HYDROCHLORIDE
Rating	New	New
Pharmacy pays	—	~$85.16 /30
Type	RX	RX
Active ingredient	PENICILLAMINE	TRIENTINE HYDROCHLORIDE
Manufacturer	Mylan Speciality LP	Watson Labs Teva
Dosage forms	Tablet	Capsule
Drug class	Antirheumatic Agent	Copper Chelator
Boxed warning	Boxed warning	None
Treats	Rheumatoid Arthritis, Cystinuria, Hepatolenticular Degeneration	Hepatolenticular Degeneration, Nervous System Heavy Metal Poisoning

depen trientine hydrochloride

Rating

New

Pharmacy pays

—

~$85.16 /30

Type

Active ingredient

PENICILLAMINE

TRIENTINE HYDROCHLORIDE

Manufacturer

Mylan Speciality LP

Watson Labs Teva

Dosage forms

Tablet

Capsule

Drug class

Antirheumatic Agent

Copper Chelator

Boxed warning

None

Treats

Rheumatoid Arthritis, Cystinuria, Hepatolenticular Degeneration

Hepatolenticular Degeneration, Nervous System Heavy Metal Poisoning

Frequently asked questions

What is the difference between Depen and Trientine Hydrochloride?

Depen contains Penicillamine, while Trientine Hydrochloride contains Trientine Hydrochloride — they have different active ingredients.

Ratings are based on FDA regulatory (recall-safety) data. This comparison is for general reference only — not medical advice. Always consult a licensed professional before choosing or switching a medication.