DEPAKOTE vs NEURONTIN

Independent side-by-side comparison.

Rated against independent regulatory sources·Last updated August 21, 2026·How we rate

Possible drug interaction. DEPAKOTE and NEURONTIN are different prescription medicines. Combining or switching between them can cause interactions — talk to a pharmacist or prescriber before making changes. This page is not medical advice.

Attribute	DEPAKOTE	NEURONTIN
Rating	72/100	New
Pharmacy pays	~$5.99 /30	~$1.22 /30
Type	RX	RX
Active ingredient	DIVALPROEX SODIUM	GABAPENTIN
Manufacturer	Abbvie	Parke Davis
Dosage forms	Tablet, delayed release	Capsule, Solution, Tablet
Drug class	Anti-Epileptic Agent	Anti-Epileptic Agent
Boxed warning	Boxed warning	None
Half-life	about 9 to 16 hours (the label's mean terminal half-life range for valproate monotherapy)	about 5 to 7 hours in adults with normal kidney function
Treats	Bipolar Disorder, Epilepsy, Absence Epilepsy	Bipolar Disorder, Partial Epilepsies, Phobic Disorders

depakote neurontin

Rating

72/100

New

Pharmacy pays

~$5.99 /30

~$1.22 /30

Type

Active ingredient

DIVALPROEX SODIUM

GABAPENTIN

Manufacturer

Abbvie

Parke Davis

Dosage forms

Tablet, delayed release

Capsule, Solution, Tablet

Drug class

Anti-Epileptic Agent

Boxed warning

None

Half-life

about 9 to 16 hours (the label's mean terminal half-life range for valproate monotherapy)

about 5 to 7 hours in adults with normal kidney function

Treats

Bipolar Disorder, Epilepsy, Absence Epilepsy

Bipolar Disorder, Partial Epilepsies, Phobic Disorders

Frequently asked questions

Which is cheaper, Depakote or Neurontin?

Neurontin costs pharmacies less to acquire — about $1.22 vs $5.99 for a 30-count supply, per the CMS NADAC survey. That gap is in the pharmacy's cost of goods, not necessarily in what you pay: your price is set afterwards by your insurer and the pharmacy.

What is the difference between Depakote and Neurontin?

Depakote contains Divalproex Sodium, while Neurontin contains Gabapentin — they have different active ingredients.

Ratings are based on FDA regulatory (recall-safety) data. This comparison is for general reference only — not medical advice. Always consult a licensed professional before choosing or switching a medication.