DEPAKOTE vs MILONTIN

Independent side-by-side comparison.

Rated against independent regulatory sources·Last updated August 23, 2026·How we rate

Possible drug interaction. DEPAKOTE and MILONTIN are different prescription medicines. Combining or switching between them can cause interactions — talk to a pharmacist or prescriber before making changes. This page is not medical advice.

Attribute	DEPAKOTE	MILONTIN
Rating	72/100	New
Pharmacy pays	~$5.99 /30	—
Type	RX	RX
Active ingredient	DIVALPROEX SODIUM	PHENSUXIMIDE
Manufacturer	Abbvie	Parke Davis
Dosage forms	Tablet, delayed release	Capsule
Drug class	Anti-Epileptic Agent	—
Boxed warning	Boxed warning	None
Half-life	about 9 to 16 hours (the label's mean terminal half-life range for valproate monotherapy)	—
Treats	Bipolar Disorder, Epilepsy, Absence Epilepsy	Absence Epilepsy

depakote milontin

Rating

72/100

New

Pharmacy pays

~$5.99 /30

—

Type

Active ingredient

DIVALPROEX SODIUM

PHENSUXIMIDE

Manufacturer

Abbvie

Parke Davis

Dosage forms

Tablet, delayed release

Capsule

Drug class

Anti-Epileptic Agent

—

Boxed warning

None

Half-life

about 9 to 16 hours (the label's mean terminal half-life range for valproate monotherapy)

—

Treats

Bipolar Disorder, Epilepsy, Absence Epilepsy

Absence Epilepsy

Frequently asked questions

What is the difference between Depakote and Milontin?

Depakote contains Divalproex Sodium, while Milontin contains Phensuximide — they have different active ingredients.

Ratings are based on FDA regulatory (recall-safety) data. This comparison is for general reference only — not medical advice. Always consult a licensed professional before choosing or switching a medication.