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DEPAKOTE vs HORIZANT

Independent side-by-side comparison.

Rated against independent regulatory sources·Last updated August 20, 2026·How we rate

Possible drug interaction. DEPAKOTE and HORIZANT are different prescription medicines. Combining or switching between them can cause interactions — talk to a pharmacist or prescriber before making changes. This page is not medical advice.

depakotehorizant

Rating

72/100
70/100

Pharmacy pays

~$5.99 /30
—

Type

RX
RX

Active ingredient

DIVALPROEX SODIUM
GABAPENTIN ENACARBIL

Manufacturer

Abbvie
Azurity

Dosage forms

Tablet, delayed release
Tablet, extended release

Drug class

Anti-Epileptic Agent
—

Boxed warning

Boxed warning
None

Half-life

about 9 to 16 hours (the label's mean terminal half-life range for valproate monotherapy)
about 5 to 7 hours in adults with normal kidney function

Treats

Bipolar Disorder, Epilepsy, Absence Epilepsy
Bipolar Disorder, Partial Epilepsies, Phobic Disorders

Frequently asked questions

Which is better-rated, Depakote or Horizant?

By our independent rating, Depakote scores higher — 3.6 vs 3.5 out of 5 for Horizant. Ratings are based on FDA regulatory (recall-safety) data.

What is the difference between Depakote and Horizant?

Depakote contains Divalproex Sodium, while Horizant contains Gabapentin Enacarbil — they have different active ingredients.

Ratings are based on FDA regulatory (recall-safety) data. This comparison is for general reference only — not medical advice. Always consult a licensed professional before choosing or switching a medication.