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DEPAKOTE vs GABITRIL

Independent side-by-side comparison.

Rated against independent regulatory sources·Last updated August 12, 2026·How we rate

Possible drug interaction. DEPAKOTE and GABITRIL are different prescription medicines. Combining or switching between them can cause interactions — talk to a pharmacist or prescriber before making changes. This page is not medical advice.

Rating

72/100
New

Pharmacy pays

~$5.99 /30
~$63.70 /30

Type

RX
RX

Active ingredient

DIVALPROEX SODIUM
TIAGABINE HYDROCHLORIDE

Manufacturer

Dosage forms

Tablet, delayed release
Tablet

Drug class

Anti-Epileptic Agent
Anti-Epileptic Agent

Boxed warning

Half-life

about 9 to 16 hours (the label's mean terminal half-life range for valproate monotherapy)

Treats

Bipolar Disorder, Epilepsy, Absence Epilepsy
Bipolar Disorder, Partial Epilepsies

Frequently asked questions

Which is cheaper, Depakote or Gabitril?

Depakote costs pharmacies less to acquire — about $5.99 vs $63.70 for a 30-count supply, per the CMS NADAC survey. That gap is in the pharmacy's cost of goods, not necessarily in what you pay: your price is set afterwards by your insurer and the pharmacy.

What is the difference between Depakote and Gabitril?

Depakote contains Divalproex Sodium, while Gabitril contains Tiagabine Hydrochloride — they have different active ingredients.

Ratings are based on FDA regulatory (recall-safety) data. This comparison is for general reference only — not medical advice. Always consult a licensed professional before choosing or switching a medication.