DEPAKOTE ER vs VIGAFYDE

Independent side-by-side comparison.

Rated against independent regulatory sources·Last updated August 21, 2026·How we rate

Possible drug interaction. DEPAKOTE ER and VIGAFYDE are different prescription medicines. Combining or switching between them can cause interactions — talk to a pharmacist or prescriber before making changes. This page is not medical advice.

Attribute	DEPAKOTE ER	VIGAFYDE
Rating	70/100	New
Pharmacy pays	~$5.99 /30	—
Type	RX	RX
Active ingredient	DIVALPROEX SODIUM	VIGABATRIN
Manufacturer	Abbott	Pyros Pharms
Dosage forms	Tablet, extended release	Solution
Drug class	Anti-Epileptic Agent	Anti-Epileptic Agent
Boxed warning	None	Boxed warning
Half-life	about 9 to 16 hours (the label's mean terminal half-life range for valproate monotherapy)	—
Treats	Bipolar Disorder, Epilepsy, Absence Epilepsy	Infantile Spasms, Complex Partial Epilepsy

depakote er vigafyde

Rating

70/100

New

Pharmacy pays

~$5.99 /30

—

Type

Active ingredient

DIVALPROEX SODIUM

VIGABATRIN

Manufacturer

Abbott

Pyros Pharms

Dosage forms

Tablet, extended release

Solution

Drug class

Anti-Epileptic Agent

Boxed warning

None

Boxed warning

Half-life

about 9 to 16 hours (the label's mean terminal half-life range for valproate monotherapy)

—

Treats

Bipolar Disorder, Epilepsy, Absence Epilepsy

Infantile Spasms, Complex Partial Epilepsy

Frequently asked questions

What is the difference between Depakote ER and Vigafyde?

Depakote ER contains Divalproex Sodium, while Vigafyde contains Vigabatrin — they have different active ingredients.

Ratings are based on FDA regulatory (recall-safety) data. This comparison is for general reference only — not medical advice. Always consult a licensed professional before choosing or switching a medication.