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DEPAKOTE ER vs VALPROATE SODIUM

Independent side-by-side comparison.

Rated against independent regulatory sources·Last updated August 20, 2026·How we rate

Possible drug interaction. DEPAKOTE ER and VALPROATE SODIUM are different prescription medicines. Combining or switching between them can cause interactions — talk to a pharmacist or prescriber before making changes. This page is not medical advice.

depakote ervalproate sodium

Rating

70/100
70/100

Pharmacy pays

~$5.99 /30
—

Type

RX
RX

Active ingredient

DIVALPROEX SODIUM
VALPROATE SODIUM

Manufacturer

Abbott
Sagent

Dosage forms

Tablet, extended release
Injectable, Solution

Drug class

Anti-Epileptic Agent
Anti-Epileptic Agent

Boxed warning

None
Boxed warning

Half-life

about 9 to 16 hours (the label's mean terminal half-life range for valproate monotherapy)
about 9 to 16 hours (the label's mean terminal, or elimination, half-life for valproate monotherapy after oral doses of 250 to 1,000 mg)

Treats

Bipolar Disorder, Epilepsy, Absence Epilepsy
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Frequently asked questions

Which is better-rated, Depakote ER or Valproate Sodium?

Depakote ER and Valproate Sodium are tied at 3.5 out of 5 by our independent rating.

What is the difference between Depakote ER and Valproate Sodium?

Depakote ER contains Divalproex Sodium, while Valproate Sodium contains Valproate Sodium — they have different active ingredients.

Ratings are based on FDA regulatory (recall-safety) data. This comparison is for general reference only — not medical advice. Always consult a licensed professional before choosing or switching a medication.