DEPAKOTE ER vs HORIZANT

Independent side-by-side comparison.

Rated against independent regulatory sources·Last updated August 20, 2026·How we rate

Possible drug interaction. DEPAKOTE ER and HORIZANT are different prescription medicines. Combining or switching between them can cause interactions — talk to a pharmacist or prescriber before making changes. This page is not medical advice.

Attribute	DEPAKOTE ER	HORIZANT
Rating	70/100	70/100
Pharmacy pays	~$5.99 /30	—
Type	RX	RX
Active ingredient	DIVALPROEX SODIUM	GABAPENTIN ENACARBIL
Manufacturer	Abbott	Azurity
Dosage forms	Tablet, extended release	Tablet, extended release
Drug class	Anti-Epileptic Agent	—
Boxed warning	None	None
Half-life	about 9 to 16 hours (the label's mean terminal half-life range for valproate monotherapy)	about 5 to 7 hours in adults with normal kidney function
Treats	Bipolar Disorder, Epilepsy, Absence Epilepsy	Bipolar Disorder, Partial Epilepsies, Phobic Disorders

depakote er horizant

Rating

70/100

Pharmacy pays

~$5.99 /30

—

Type

Active ingredient

DIVALPROEX SODIUM

GABAPENTIN ENACARBIL

Manufacturer

Abbott

Azurity

Dosage forms

Tablet, extended release

Drug class

Anti-Epileptic Agent

—

Boxed warning

None

Half-life

about 9 to 16 hours (the label's mean terminal half-life range for valproate monotherapy)

about 5 to 7 hours in adults with normal kidney function

Treats

Bipolar Disorder, Epilepsy, Absence Epilepsy

Bipolar Disorder, Partial Epilepsies, Phobic Disorders

Frequently asked questions

Which is better-rated, Depakote ER or Horizant?

Depakote ER and Horizant are tied at 3.5 out of 5 by our independent rating.

What is the difference between Depakote ER and Horizant?

Depakote ER contains Divalproex Sodium, while Horizant contains Gabapentin Enacarbil — they have different active ingredients.

Ratings are based on FDA regulatory (recall-safety) data. This comparison is for general reference only — not medical advice. Always consult a licensed professional before choosing or switching a medication.