DEPAKOTE ER vs GEMONIL

Independent side-by-side comparison.

Rated against independent regulatory sources·Last updated October 7, 2026·How we rate

Possible drug interaction. DEPAKOTE ER and GEMONIL are different prescription medicines. Combining or switching between them can cause interactions — talk to a pharmacist or prescriber before making changes. This page is not medical advice.

Attribute	DEPAKOTE ER	GEMONIL
Rating	72/100	72/100
Pharmacy pays	~$6.02 /30	—
Type	RX	RX
Active ingredient	DIVALPROEX SODIUM	METHARBITAL
Manufacturer	Abbott	Abbvie
Dosage forms	Tablet, extended release	Tablet
Drug class	Anti-Epileptic Agent	—
Boxed warning	None	None
Half-life	about 9 to 16 hours (the label's mean terminal half-life range for valproate monotherapy)	—
Treats	Bipolar Disorder, Epilepsy, Absence Epilepsy	Epilepsy

depakote er gemonil

Rating

72/100

Pharmacy pays

~$6.02 /30

—

Type

Active ingredient

DIVALPROEX SODIUM

METHARBITAL

Manufacturer

Abbott

Abbvie

Dosage forms

Tablet, extended release

Tablet

Drug class

Anti-Epileptic Agent

—

Boxed warning

None

Half-life

about 9 to 16 hours (the label's mean terminal half-life range for valproate monotherapy)

—

Treats

Bipolar Disorder, Epilepsy, Absence Epilepsy

Epilepsy

Frequently asked questions

Which is better-rated, Depakote ER or Gemonil?

Depakote ER and Gemonil are tied at 3.6 out of 5 by our independent rating.

What is the difference between Depakote ER and Gemonil?

Depakote ER contains Divalproex Sodium, while Gemonil contains Metharbital — they have different active ingredients.

Ratings are based on FDA regulatory (recall-safety) data. This comparison is for general reference only — not medical advice. Always consult a licensed professional before choosing or switching a medication.