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DEPAKOTE ER vs FOSPHENYTOIN SODIUM

Independent side-by-side comparison.

Rated against independent regulatory sources·Last updated August 20, 2026·How we rate

Possible drug interaction. DEPAKOTE ER and FOSPHENYTOIN SODIUM are different prescription medicines. Combining or switching between them can cause interactions — talk to a pharmacist or prescriber before making changes. This page is not medical advice.

depakote erfosphenytoin sodium

Rating

70/100
72/100

Pharmacy pays

~$5.99 /30
—

Type

RX
RX

Active ingredient

DIVALPROEX SODIUM
FOSPHENYTOIN SODIUM

Manufacturer

Abbott
Hikma

Dosage forms

Tablet, extended release
Injectable, Solution

Drug class

Anti-Epileptic Agent
Anti-Epileptic Agent

Boxed warning

None
Boxed warning

Half-life

about 9 to 16 hours (the label's mean terminal half-life range for valproate monotherapy)
—

Treats

Bipolar Disorder, Epilepsy, Absence Epilepsy
Seizures, Status Epilepticus

Frequently asked questions

Which is better-rated, Depakote ER or Fosphenytoin Sodium?

By our independent rating, Fosphenytoin Sodium scores higher — 3.6 vs 3.5 out of 5 for Depakote ER. Ratings are based on FDA regulatory (recall-safety) data.

What is the difference between Depakote ER and Fosphenytoin Sodium?

Depakote ER contains Divalproex Sodium, while Fosphenytoin Sodium contains Fosphenytoin Sodium — they have different active ingredients.

Ratings are based on FDA regulatory (recall-safety) data. This comparison is for general reference only — not medical advice. Always consult a licensed professional before choosing or switching a medication.