DEPAKOTE ER vs DIVALPROEX SODIUM

Independent side-by-side comparison.

Rated against independent regulatory sources·Last updated August 20, 2026·How we rate

Attribute	DEPAKOTE ER	DIVALPROEX SODIUM
Rating	70/100	68/100
Pharmacy pays	~$5.99 /30	~$5.99 /30
Type	RX	RX
Active ingredient	DIVALPROEX SODIUM	DIVALPROEX SODIUM
Manufacturer	Abbott	Aurobindo Pharma Ltd
Dosage forms	Tablet, extended release	Capsule, Oral pellets, Capsule, delayed release, Tablet, delayed release, Tablet, extended release
Drug class	Anti-Epileptic Agent	Anti-Epileptic Agent
Boxed warning	None	Boxed warning
Half-life	about 9 to 16 hours (the label's mean terminal half-life range for valproate monotherapy)	about 9 to 16 hours (the label's mean terminal half-life range for valproate monotherapy)
Treats	Bipolar Disorder, Epilepsy, Absence Epilepsy	Bipolar Disorder, Epilepsy, Absence Epilepsy

depakote er divalproex sodium

Rating

70/100

68/100

Pharmacy pays

~$5.99 /30

Type

Active ingredient

DIVALPROEX SODIUM

Manufacturer

Abbott

Aurobindo Pharma Ltd

Dosage forms

Tablet, extended release

Capsule, Oral pellets, Capsule, delayed release, Tablet, delayed release, Tablet, extended release

Drug class

Anti-Epileptic Agent

Boxed warning

None

Boxed warning

Half-life

about 9 to 16 hours (the label's mean terminal half-life range for valproate monotherapy)

Treats

Bipolar Disorder, Epilepsy, Absence Epilepsy

Frequently asked questions

Which is better-rated, Depakote ER or Divalproex Sodium?

By our independent rating, Depakote ER scores higher — 3.5 vs 3.4 out of 5 for Divalproex Sodium. Ratings are based on FDA regulatory (recall-safety) data.

Which is cheaper, Depakote ER or Divalproex Sodium?

Pharmacies pay about the same to acquire either one — roughly $5.99 for a 30-count supply, per the CMS NADAC survey. That is not what you will be charged: your price is set by your insurer and the pharmacy, not by what the drug cost them.

What is the difference between Depakote ER and Divalproex Sodium?

Both Depakote ER and Divalproex Sodium share the active ingredient Divalproex Sodium.

Ratings are based on FDA regulatory (recall-safety) data. This comparison is for general reference only — not medical advice. Always consult a licensed professional before choosing or switching a medication.