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DEPAKOTE CP vs ZONISADE

Independent side-by-side comparison.

Rated against independent regulatory sources·Last updated August 23, 2026·How we rate

Possible drug interaction. DEPAKOTE CP and ZONISADE are different prescription medicines. Combining or switching between them can cause interactions — talk to a pharmacist or prescriber before making changes. This page is not medical advice.

depakote cpzonisade

Rating

70/100
70/100

Pharmacy pays

~$5.99 /30
~$3.16 /30

Type

RX
RX

Active ingredient

DIVALPROEX SODIUM
ZONISAMIDE

Manufacturer

Abbott
Azurity

Dosage forms

Tablet, delayed release
Suspension

Drug class

Anti-Epileptic Agent
Anti-Epileptic Agent

Boxed warning

None
None

Half-life

about 9 to 16 hours (the label's mean terminal half-life range for valproate monotherapy)
—

Treats

Bipolar Disorder, Epilepsy, Absence Epilepsy
Partial Epilepsies

Frequently asked questions

Which is better-rated, Depakote Cp or Zonisade?

Depakote Cp and Zonisade are tied at 3.5 out of 5 by our independent rating.

Which is cheaper, Depakote Cp or Zonisade?

Zonisade costs pharmacies less to acquire — about $3.16 vs $5.99 for a 30-count supply, per the CMS NADAC survey. That gap is in the pharmacy's cost of goods, not necessarily in what you pay: your price is set afterwards by your insurer and the pharmacy.

What is the difference between Depakote Cp and Zonisade?

Depakote Cp contains Divalproex Sodium, while Zonisade contains Zonisamide — they have different active ingredients.

Ratings are based on FDA regulatory (recall-safety) data. This comparison is for general reference only — not medical advice. Always consult a licensed professional before choosing or switching a medication.