DEPAKOTE CP vs LAMICTAL CD

Independent side-by-side comparison.

Rated against independent regulatory sources·Last updated August 21, 2026·How we rate

Possible drug interaction. DEPAKOTE CP and LAMICTAL CD are different prescription medicines. Combining or switching between them can cause interactions — talk to a pharmacist or prescriber before making changes. This page is not medical advice.

Attribute	DEPAKOTE CP	LAMICTAL CD
Rating	70/100	70/100
Pharmacy pays	~$5.99 /30	~$4.39 /30
Type	RX	RX
Active ingredient	DIVALPROEX SODIUM	LAMOTRIGINE
Manufacturer	Abbott	Glaxosmithkline
Dosage forms	Tablet, delayed release	Tablet
Drug class	Anti-Epileptic Agent	Anti-Epileptic Agent
Boxed warning	None	Boxed warning
Half-life	about 9 to 16 hours (the label's mean terminal half-life range for valproate monotherapy)	about 25 to 33 hours in healthy adults taking no other medications — the label reports a mean elimination half-life of 32.8 hours after a single dose (individual range 14 to 103 hours) and 25.4 hours with repeat dosing (range 11.6 to 61.6 hours), since lamotrigine induces its own metabolism
Treats	Bipolar Disorder, Epilepsy, Absence Epilepsy	Bipolar Disorder, Partial Epilepsies, Seizures

depakote cp lamictal cd

Rating

70/100

Pharmacy pays

~$5.99 /30

~$4.39 /30

Type

Active ingredient

DIVALPROEX SODIUM

LAMOTRIGINE

Manufacturer

Abbott

Glaxosmithkline

Dosage forms

Tablet, delayed release

Tablet

Drug class

Anti-Epileptic Agent

Boxed warning

None

Boxed warning

Half-life

about 9 to 16 hours (the label's mean terminal half-life range for valproate monotherapy)

about 25 to 33 hours in healthy adults taking no other medications — the label reports a mean elimination half-life of 32.8 hours after a single dose (individual range 14 to 103 hours) and 25.4 hours with repeat dosing (range 11.6 to 61.6 hours), since lamotrigine induces its own metabolism

Treats

Bipolar Disorder, Epilepsy, Absence Epilepsy

Bipolar Disorder, Partial Epilepsies, Seizures

Frequently asked questions

Which is better-rated, Depakote Cp or Lamictal Cd?

Depakote Cp and Lamictal Cd are tied at 3.5 out of 5 by our independent rating.

Which is cheaper, Depakote Cp or Lamictal Cd?

Lamictal Cd costs pharmacies less to acquire — about $4.39 vs $5.99 for a 30-count supply, per the CMS NADAC survey. That gap is in the pharmacy's cost of goods, not necessarily in what you pay: your price is set afterwards by your insurer and the pharmacy.

What is the difference between Depakote Cp and Lamictal Cd?

Depakote Cp contains Divalproex Sodium, while Lamictal Cd contains Lamotrigine — they have different active ingredients.

Ratings are based on FDA regulatory (recall-safety) data. This comparison is for general reference only — not medical advice. Always consult a licensed professional before choosing or switching a medication.