DEPAKENE vs MYSOLINE

Independent side-by-side comparison.

Rated against independent regulatory sources·Last updated August 23, 2026·How we rate

Possible drug interaction. DEPAKENE and MYSOLINE are different prescription medicines. Combining or switching between them can cause interactions — talk to a pharmacist or prescriber before making changes. This page is not medical advice.

Attribute	DEPAKENE	MYSOLINE
Rating	72/100	70/100
Pharmacy pays	~$1.02 /30	~$2.89 /30
Type	RX	RX
Active ingredient	VALPROIC ACID	PRIMIDONE
Manufacturer	Abbvie	Valeant Pharm Intl
Dosage forms	Syrup, Capsule	Tablet
Drug class	Anti-Epileptic Agent	Anti-Epileptic Agent
Boxed warning	None	None
Treats	Alzheimer Disease, Bipolar Disorder, Epilepsy	Partial Epilepsies, Tonic-Clonic Epilepsy, Tremor

depakene mysoline

Rating

72/100

70/100

Pharmacy pays

~$1.02 /30

~$2.89 /30

Type

Active ingredient

VALPROIC ACID

PRIMIDONE

Manufacturer

Abbvie

Valeant Pharm Intl

Dosage forms

Syrup, Capsule

Tablet

Drug class

Anti-Epileptic Agent

Boxed warning

None

Treats

Alzheimer Disease, Bipolar Disorder, Epilepsy

Partial Epilepsies, Tonic-Clonic Epilepsy, Tremor

Frequently asked questions

Which is better-rated, Depakene or Mysoline?

By our independent rating, Depakene scores higher — 3.6 vs 3.5 out of 5 for Mysoline. Ratings are based on FDA regulatory (recall-safety) data.

Which is cheaper, Depakene or Mysoline?

Depakene costs pharmacies less to acquire — about $1.02 vs $2.89 for a 30-count supply, per the CMS NADAC survey. That gap is in the pharmacy's cost of goods, not necessarily in what you pay: your price is set afterwards by your insurer and the pharmacy.

What is the difference between Depakene and Mysoline?

Depakene contains Valproic Acid, while Mysoline contains Primidone — they have different active ingredients.

Ratings are based on FDA regulatory (recall-safety) data. This comparison is for general reference only — not medical advice. Always consult a licensed professional before choosing or switching a medication.