DEPAKENE vs LAMICTAL

Independent side-by-side comparison.

Rated against independent regulatory sources·Last updated October 6, 2026·How we rate

Possible drug interaction. DEPAKENE and LAMICTAL are different prescription medicines. Combining or switching between them can cause interactions — talk to a pharmacist or prescriber before making changes. This page is not medical advice.

Attribute	DEPAKENE	LAMICTAL
Rating	72/100	72/100
Pharmacy pays	~$1.01 /30	~$4.43 /30
Type	RX	RX
Active ingredient	VALPROIC ACID	LAMOTRIGINE
Manufacturer	Abbvie	Glaxosmithkline
Dosage forms	Syrup, Capsule	Tablet, Kit
Drug class	Anti-Epileptic Agent	Anti-Epileptic Agent
Boxed warning	None	Boxed warning
Half-life	—	about 25 to 33 hours in healthy adults taking no other medications — the label reports a mean elimination half-life of 32.8 hours after a single dose (individual range 14 to 103 hours) and 25.4 hours with repeat dosing (range 11.6 to 61.6 hours), since lamotrigine induces its own metabolism
Treats	Alzheimer Disease, Bipolar Disorder, Epilepsy	Bipolar Disorder, Partial Epilepsies, Seizures

depakene lamictal

Rating

72/100

Pharmacy pays

~$1.01 /30

~$4.43 /30

Type

Active ingredient

VALPROIC ACID

LAMOTRIGINE

Manufacturer

Abbvie

Glaxosmithkline

Dosage forms

Syrup, Capsule

Tablet, Kit

Drug class

Anti-Epileptic Agent

Boxed warning

None

Boxed warning

Half-life

—

about 25 to 33 hours in healthy adults taking no other medications — the label reports a mean elimination half-life of 32.8 hours after a single dose (individual range 14 to 103 hours) and 25.4 hours with repeat dosing (range 11.6 to 61.6 hours), since lamotrigine induces its own metabolism

Treats

Alzheimer Disease, Bipolar Disorder, Epilepsy

Bipolar Disorder, Partial Epilepsies, Seizures

Frequently asked questions

Which is better-rated, Depakene or Lamictal?

Depakene and Lamictal are tied at 3.6 out of 5 by our independent rating.

Which is cheaper, Depakene or Lamictal?

Depakene costs pharmacies less to acquire — about $1.01 vs $4.43 for a 30-count supply, per the CMS NADAC survey. That gap is in the pharmacy's cost of goods, not necessarily in what you pay: your price is set afterwards by your insurer and the pharmacy.

What is the difference between Depakene and Lamictal?

Depakene contains Valproic Acid, while Lamictal contains Lamotrigine — they have different active ingredients.

Ratings are based on FDA regulatory (recall-safety) data. This comparison is for general reference only — not medical advice. Always consult a licensed professional before choosing or switching a medication.