DEPAKENE vs GRALISE

Independent side-by-side comparison.

Rated against independent regulatory sources·Last updated August 21, 2026·How we rate

Possible drug interaction. DEPAKENE and GRALISE are different prescription medicines. Combining or switching between them can cause interactions — talk to a pharmacist or prescriber before making changes. This page is not medical advice.

Attribute	DEPAKENE	GRALISE
Rating	72/100	New
Pharmacy pays	~$1.02 /30	~$1.22 /30
Type	RX	RX
Active ingredient	VALPROIC ACID	GABAPENTIN
Manufacturer	Abbvie	Almatica
Dosage forms	Syrup, Capsule	Tablet
Drug class	Anti-Epileptic Agent	Anti-Epileptic Agent
Boxed warning	None	None
Half-life	—	about 5 to 7 hours in adults with normal kidney function
Treats	Alzheimer Disease, Bipolar Disorder, Epilepsy	Bipolar Disorder, Partial Epilepsies, Phobic Disorders

depakene gralise

Rating

72/100

New

Pharmacy pays

~$1.02 /30

~$1.22 /30

Type

Active ingredient

VALPROIC ACID

GABAPENTIN

Manufacturer

Abbvie

Almatica

Dosage forms

Syrup, Capsule

Tablet

Drug class

Anti-Epileptic Agent

Boxed warning

None

Half-life

—

about 5 to 7 hours in adults with normal kidney function

Treats

Alzheimer Disease, Bipolar Disorder, Epilepsy

Bipolar Disorder, Partial Epilepsies, Phobic Disorders

Frequently asked questions

Which is cheaper, Depakene or Gralise?

Depakene costs pharmacies less to acquire — about $1.02 vs $1.22 for a 30-count supply, per the CMS NADAC survey. That gap is in the pharmacy's cost of goods, not necessarily in what you pay: your price is set afterwards by your insurer and the pharmacy.

What is the difference between Depakene and Gralise?

Depakene contains Valproic Acid, while Gralise contains Gabapentin — they have different active ingredients.

Ratings are based on FDA regulatory (recall-safety) data. This comparison is for general reference only — not medical advice. Always consult a licensed professional before choosing or switching a medication.