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DEPAKENE vs DEPAKOTE

Independent side-by-side comparison.

Rated against independent regulatory sources·Last updated August 20, 2026·How we rate

Possible drug interaction. DEPAKENE and DEPAKOTE are different prescription medicines. Combining or switching between them can cause interactions — talk to a pharmacist or prescriber before making changes. This page is not medical advice.

Rating

72/100
72/100

Pharmacy pays

~$1.02 /30
~$5.99 /30

Type

RX
RX

Active ingredient

VALPROIC ACID
DIVALPROEX SODIUM

Manufacturer

Dosage forms

Syrup, Capsule
Tablet, delayed release

Drug class

Anti-Epileptic Agent
Anti-Epileptic Agent

Boxed warning

Half-life

about 9 to 16 hours (the label's mean terminal half-life range for valproate monotherapy)

Treats

Alzheimer Disease, Bipolar Disorder, Epilepsy
Bipolar Disorder, Epilepsy, Absence Epilepsy

Frequently asked questions

Which is better-rated, Depakene or Depakote?

Depakene and Depakote are tied at 3.6 out of 5 by our independent rating.

Which is cheaper, Depakene or Depakote?

Depakene costs pharmacies less to acquire — about $1.02 vs $5.99 for a 30-count supply, per the CMS NADAC survey. That gap is in the pharmacy's cost of goods, not necessarily in what you pay: your price is set afterwards by your insurer and the pharmacy.

What is the difference between Depakene and Depakote?

Depakene contains Valproic Acid, while Depakote contains Divalproex Sodium — they have different active ingredients.

Ratings are based on FDA regulatory (recall-safety) data. This comparison is for general reference only — not medical advice. Always consult a licensed professional before choosing or switching a medication.