DEPACON vs DEPAKOTE ER

Independent side-by-side comparison.

Rated against independent regulatory sources·Last updated October 6, 2026·How we rate

Possible drug interaction. DEPACON and DEPAKOTE ER are different prescription medicines. Combining or switching between them can cause interactions — talk to a pharmacist or prescriber before making changes. This page is not medical advice.

Attribute	DEPACON	DEPAKOTE ER
Rating	72/100	72/100
Pharmacy pays	—	~$6.02 /30
Type	RX	RX
Active ingredient	VALPROATE SODIUM	DIVALPROEX SODIUM
Manufacturer	Abbvie	Abbott
Dosage forms	Injectable	Tablet, extended release
Drug class	Anti-Epileptic Agent	Anti-Epileptic Agent
Boxed warning	None	None
Half-life	about 9 to 16 hours (the label's mean terminal, or elimination, half-life for valproate monotherapy after oral doses of 250 to 1,000 mg)	about 9 to 16 hours (the label's mean terminal half-life range for valproate monotherapy)
Treats	—	Bipolar Disorder, Epilepsy, Absence Epilepsy

depacon depakote er

Rating

72/100

Pharmacy pays

—

~$6.02 /30

Type

Active ingredient

VALPROATE SODIUM

DIVALPROEX SODIUM

Manufacturer

Abbvie

Abbott

Dosage forms

Injectable

Tablet, extended release

Drug class

Anti-Epileptic Agent

Boxed warning

None

Half-life

about 9 to 16 hours (the label's mean terminal, or elimination, half-life for valproate monotherapy after oral doses of 250 to 1,000 mg)

about 9 to 16 hours (the label's mean terminal half-life range for valproate monotherapy)

Treats

—

Bipolar Disorder, Epilepsy, Absence Epilepsy

Frequently asked questions

Which is better-rated, Depacon or Depakote ER?

Depacon and Depakote ER are tied at 3.6 out of 5 by our independent rating.

What is the difference between Depacon and Depakote ER?

Depacon contains Valproate Sodium, while Depakote ER contains Divalproex Sodium — they have different active ingredients.

Ratings are based on FDA regulatory (recall-safety) data. This comparison is for general reference only — not medical advice. Always consult a licensed professional before choosing or switching a medication.