DEPACON vs DEPAKOTE

Independent side-by-side comparison.

Rated against independent regulatory sources·Last updated August 22, 2026·How we rate

Possible drug interaction. DEPACON and DEPAKOTE are different prescription medicines. Combining or switching between them can cause interactions — talk to a pharmacist or prescriber before making changes. This page is not medical advice.

Attribute	DEPACON	DEPAKOTE
Rating	72/100	72/100
Pharmacy pays	—	~$5.99 /30
Type	RX	RX
Active ingredient	VALPROATE SODIUM	DIVALPROEX SODIUM
Manufacturer	Abbvie	Abbvie
Dosage forms	Injectable	Tablet, delayed release
Drug class	Anti-Epileptic Agent	Anti-Epileptic Agent
Boxed warning	None	Boxed warning
Half-life	about 9 to 16 hours (the label's mean terminal, or elimination, half-life for valproate monotherapy after oral doses of 250 to 1,000 mg)	about 9 to 16 hours (the label's mean terminal half-life range for valproate monotherapy)
Treats	—	Bipolar Disorder, Epilepsy, Absence Epilepsy

depacon depakote

Rating

72/100

Pharmacy pays

—

~$5.99 /30

Type

Active ingredient

VALPROATE SODIUM

DIVALPROEX SODIUM

Manufacturer

Abbvie

Dosage forms

Injectable

Tablet, delayed release

Drug class

Anti-Epileptic Agent

Boxed warning

None

Boxed warning

Half-life

about 9 to 16 hours (the label's mean terminal, or elimination, half-life for valproate monotherapy after oral doses of 250 to 1,000 mg)

about 9 to 16 hours (the label's mean terminal half-life range for valproate monotherapy)

Treats

—

Bipolar Disorder, Epilepsy, Absence Epilepsy

Frequently asked questions

Which is better-rated, Depacon or Depakote?

Depacon and Depakote are tied at 3.6 out of 5 by our independent rating.

What is the difference between Depacon and Depakote?

Depacon contains Valproate Sodium, while Depakote contains Divalproex Sodium — they have different active ingredients.

Ratings are based on FDA regulatory (recall-safety) data. This comparison is for general reference only — not medical advice. Always consult a licensed professional before choosing or switching a medication.