DEMI-REGROTON vs RETIN-A

Independent side-by-side comparison.

Rated against independent regulatory sources·Last updated October 8, 2026·How we rate

Possible drug interaction. DEMI-REGROTON and RETIN-A are different prescription medicines. Combining or switching between them can cause interactions — talk to a pharmacist or prescriber before making changes. This page is not medical advice.

Attribute	DEMI-REGROTON	RETIN-A
Rating	70/100	74/100
Pharmacy pays	~$2.67 /30	$1.05 /g
Type	RX	RX
Active ingredient	CHLORTHALIDONE AND RESERPINE	TRETINOIN
Manufacturer	Sanofi Aventis US	Valeant Pharm Intl
Dosage forms	Tablet	Topical
Drug class	—	Retinoid
Boxed warning	None	None
Half-life	about 40 hours on average (the label reports a mean half-life of 40 hours after a 50–200 mg dose, and an elimination half-life of 53 hours after 50 mg and 60 hours after 100 mg)	—
Treats	—	Acne Vulgaris, Facial Dermatoses, Acute Promyelocytic Leukemia

demi-regroton retin-a

Rating

70/100

74/100

Pharmacy pays

~$2.67 /30

$1.05 /g

Type

Active ingredient

CHLORTHALIDONE AND RESERPINE

TRETINOIN

Manufacturer

Sanofi Aventis US

Valeant Pharm Intl

Dosage forms

Tablet

Topical

Drug class

—

Retinoid

Boxed warning

None

Half-life

about 40 hours on average (the label reports a mean half-life of 40 hours after a 50–200 mg dose, and an elimination half-life of 53 hours after 50 mg and 60 hours after 100 mg)

—

Treats

—

Acne Vulgaris, Facial Dermatoses, Acute Promyelocytic Leukemia

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Frequently asked questions

Which is better-rated, Demi-Regroton or Retin-A?

By our independent rating, Retin-A scores higher — 3.7 vs 3.5 out of 5 for Demi-Regroton. Ratings are based on FDA regulatory (recall-safety) data.

What is the difference between Demi-Regroton and Retin-A?

Demi-Regroton contains Chlorthalidone and Reserpine, while Retin-A contains Tretinoin — they have different active ingredients.

Ratings are based on FDA regulatory (recall-safety) data. This comparison is for general reference only — not medical advice. Always consult a licensed professional before choosing or switching a medication.