DEMI-REGROTON vs MYSOLINE

Independent side-by-side comparison.

Rated against independent regulatory sources·Last updated October 8, 2026·How we rate

Possible drug interaction. DEMI-REGROTON and MYSOLINE are different prescription medicines. Combining or switching between them can cause interactions — talk to a pharmacist or prescriber before making changes. This page is not medical advice.

Attribute	DEMI-REGROTON	MYSOLINE
Rating	70/100	74/100
Pharmacy pays	~$2.67 /30	~$2.89 /30
Type	RX	RX
Active ingredient	CHLORTHALIDONE AND RESERPINE	PRIMIDONE
Manufacturer	Sanofi Aventis US	Valeant Pharm Intl
Dosage forms	Tablet	Tablet
Drug class	—	Anti-Epileptic Agent
Boxed warning	None	None
Half-life	about 40 hours on average (the label reports a mean half-life of 40 hours after a 50–200 mg dose, and an elimination half-life of 53 hours after 50 mg and 60 hours after 100 mg)	—
Treats	—	Partial Epilepsies, Tonic-Clonic Epilepsy, Tremor

demi-regroton mysoline

Rating

70/100

74/100

Pharmacy pays

~$2.67 /30

~$2.89 /30

Type

Active ingredient

CHLORTHALIDONE AND RESERPINE

PRIMIDONE

Manufacturer

Sanofi Aventis US

Valeant Pharm Intl

Dosage forms

Tablet

Drug class

—

Anti-Epileptic Agent

Boxed warning

None

Half-life

about 40 hours on average (the label reports a mean half-life of 40 hours after a 50–200 mg dose, and an elimination half-life of 53 hours after 50 mg and 60 hours after 100 mg)

—

Treats

—

Partial Epilepsies, Tonic-Clonic Epilepsy, Tremor

Frequently asked questions

Which is better-rated, Demi-Regroton or Mysoline?

By our independent rating, Mysoline scores higher — 3.7 vs 3.5 out of 5 for Demi-Regroton. Ratings are based on FDA regulatory (recall-safety) data.

Which is cheaper, Demi-Regroton or Mysoline?

Demi-Regroton costs pharmacies less to acquire — about $2.67 vs $2.89 for a 30-count supply, per the CMS NADAC survey. That gap is in the pharmacy's cost of goods, not necessarily in what you pay: your price is set afterwards by your insurer and the pharmacy.

What is the difference between Demi-Regroton and Mysoline?

Demi-Regroton contains Chlorthalidone and Reserpine, while Mysoline contains Primidone — they have different active ingredients.

Ratings are based on FDA regulatory (recall-safety) data. This comparison is for general reference only — not medical advice. Always consult a licensed professional before choosing or switching a medication.