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DEMEROL vs DURAGESIC-100

Independent side-by-side comparison.

Rated against independent regulatory sources·Last updated August 23, 2026·How we rate

Possible drug interaction. DEMEROL and DURAGESIC-100 are different prescription medicines. Combining or switching between them can cause interactions — talk to a pharmacist or prescriber before making changes. This page is not medical advice.

Rating

60/100
70/100

Pharmacy pays

$0.16 /mL
$9.51 /mL

Type

RX
RX

Active ingredient

MEPERIDINE HYDROCHLORIDE
FENTANYL

Dosage forms

Injectable
Film, extended release

Drug class

Opioid Agonist
Opioid Agonist

Boxed warning

Treats

Pain
Pain

Frequently asked questions

Which is better-rated, Demerol or Duragesic-100?

By our independent rating, Duragesic-100 scores higher — 3.5 vs 3.0 out of 5 for Demerol. Ratings are based on FDA regulatory (recall-safety) data.

Which is cheaper, Demerol or Duragesic-100?

Demerol costs pharmacies less to acquire — about $0.16 vs $9.51 per ml, per the CMS NADAC survey. That gap is in the pharmacy's cost of goods, not necessarily in what you pay: your price is set afterwards by your insurer and the pharmacy.

What is the difference between Demerol and Duragesic-100?

Demerol contains Meperidine Hydrochloride, while Duragesic-100 contains Fentanyl — they have different active ingredients.

Ratings are based on FDA regulatory (recall-safety) data. This comparison is for general reference only — not medical advice. Always consult a licensed professional before choosing or switching a medication.