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DEMEROL vs DOLOPHINE HYDROCHLORIDE

Independent side-by-side comparison.

Rated against independent regulatory sources·Last updated August 23, 2026·How we rate

Possible drug interaction. DEMEROL and DOLOPHINE HYDROCHLORIDE are different prescription medicines. Combining or switching between them can cause interactions — talk to a pharmacist or prescriber before making changes. This page is not medical advice.

Rating

60/100
72/100

Pharmacy pays

$0.16 /mL
$0.18 /mL

Type

RX
RX

Active ingredient

MEPERIDINE HYDROCHLORIDE
METHADONE HYDROCHLORIDE

Manufacturer

Dosage forms

Injectable
Tablet, Syrup

Drug class

Opioid Agonist
Opioid Agonist

Boxed warning

Half-life

about 8 to 59 hours (terminal/elimination half-life; a very wide range)

Treats

Pain
Opioid-Related Disorders, Intractable Pain

Frequently asked questions

Which is better-rated, Demerol or Dolophine Hydrochloride?

By our independent rating, Dolophine Hydrochloride scores higher — 3.6 vs 3.0 out of 5 for Demerol. Ratings are based on FDA regulatory (recall-safety) data.

Which is cheaper, Demerol or Dolophine Hydrochloride?

Demerol costs pharmacies less to acquire — about $0.16 vs $0.18 per ml, per the CMS NADAC survey. That gap is in the pharmacy's cost of goods, not necessarily in what you pay: your price is set afterwards by your insurer and the pharmacy.

What is the difference between Demerol and Dolophine Hydrochloride?

Demerol contains Meperidine Hydrochloride, while Dolophine Hydrochloride contains Methadone Hydrochloride — they have different active ingredients.

Ratings are based on FDA regulatory (recall-safety) data. This comparison is for general reference only — not medical advice. Always consult a licensed professional before choosing or switching a medication.