DELESTROGEN vs TOLAK

Independent side-by-side comparison.

Rated against independent regulatory sources·Last updated August 12, 2026·How we rate

Possible drug interaction. DELESTROGEN and TOLAK are different prescription medicines. Combining or switching between them can cause interactions — talk to a pharmacist or prescriber before making changes. This page is not medical advice.

Attribute	DELESTROGEN	TOLAK
Rating	New	72/100
Pharmacy pays	$22.37 /mL	$0.61 /mL
Type	RX	RX
Active ingredient	ESTRADIOL VALERATE	FLUOROURACIL
Manufacturer	Ph Health	Hill Dermaceuticals
Dosage forms	Injectable	Topical
Drug class	—	Nucleoside Metabolic Inhibitor
Boxed warning	Boxed warning	None
Treats	Breast Neoplasms, Hypogonadism, Premature Menopause	Breast Neoplasms, Basal Cell Carcinoma, Colonic Neoplasms

delestrogen tolak

Rating

New

72/100

Pharmacy pays

$22.37 /mL

$0.61 /mL

Type

Active ingredient

ESTRADIOL VALERATE

FLUOROURACIL

Manufacturer

Ph Health

Hill Dermaceuticals

Dosage forms

Injectable

Topical

Drug class

—

Nucleoside Metabolic Inhibitor

Boxed warning

None

Treats

Breast Neoplasms, Hypogonadism, Premature Menopause

Breast Neoplasms, Basal Cell Carcinoma, Colonic Neoplasms

Frequently asked questions

Which is cheaper, Delestrogen or Tolak?

Tolak costs pharmacies less to acquire — about $0.61 vs $22.37 per ml, per the CMS NADAC survey. That gap is in the pharmacy's cost of goods, not necessarily in what you pay: your price is set afterwards by your insurer and the pharmacy.

What is the difference between Delestrogen and Tolak?

Delestrogen contains Estradiol Valerate, while Tolak contains Fluorouracil — they have different active ingredients.

Ratings are based on FDA regulatory (recall-safety) data. This comparison is for general reference only — not medical advice. Always consult a licensed professional before choosing or switching a medication.